环境与职业医学2017，Vol.34Issue(4)：297-303,7.DOI:10.13213/j.cnki.jeom.2017.16755
男性精浆17种金属浓度与血清生殖激素水平的关系
Relationships between 17 metal concentrations in seminal plasma and serum reproductive hormone levels in men
摘要
Abstract
[Objective] To assess the associations between metal concentrations in seminal plasma and serum reproductive hormone levels in men.[Methods] A total of 746 men visiting a reproductive center in Wuhan between March and June 2013 were chosen to conduct a survey with questionnaire and laboratory test on seventeen metals in seminal plasma.Multiple linear regression models were utilized to assess the associations between the concentrations of seminal plasma metals and the levels of serum reproductive hormones (n=378).[Results] The results of multiple linear regression models showed that the cobalt,selenium,and thallium in seminal plasma of the ＞P75 group were positively associated with follicle-stimulating hormone (b=18.50.95％CI:2.00-36.00;b=17.40,95％CI:0.80-35.00;b=18.50,95％CI:3.40-37.70) compared with those of the ＜P25 group respectively.The molybdenum in seminal plasma of the ＞P75 group was positively associated with luteinizing hormone (b=12.50,95％CI:0.10-27.00) compared with that of the ＜P25 group.The chromium in seminal plasma of the ＞P75 group was suggestively inversely associated with luteinizing hormone (b=-0.90,95％CI:-22.00-1.50) compared with that of the ＜P50 group.The cadmium.cobalt,zinc.and molybdenum in seminal plasma of the ＞P75 group were positively or suggestively positively associated with sex hormone-binding globulin (b=18.00,95％CI:5.10-36.00;b=16.20,95％CI:4.00-31.00;b=7.80,95％CI:-4.00-21.00;b=13.00,95％CI:0.40-27:00) compared with those of the ＜P25 group.The tin in seminal plasma of the ＞P80 group was suggestively inversely associated with testosterone (b=-7.30,95％CI:-17.40-2.00) compared with that of the ＜P60 group,[Conclusion] Environmental exposure to cobalt,selenium,thallium,molybdenum,chromium,cadmium,zinc,and tin may be associated with alteration of serum reproductive hormone levels in men.关键词
精浆/金属/暴露/生殖激素Key words
seminal plasma/metal/exposure/reproductive hormone分类
医药卫生引用本文复制引用
黄振,汪一心,鲁文清..男性精浆17种金属浓度与血清生殖激素水平的关系[J].环境与职业医学,2017,34(4):297-303,7.基金项目
国家自然科学基金资助项目(编号:81472946) （编号:81472946）
