农药学学报2017，Vol.19Issue(2)：162-168,7.DOI:10.16801/j.issn.1008-7303.2017.0021
新型N-芳基-2-((5-((4,6-二甲基嘧啶-2-基)硫甲基)-1,3,4-噻二唑-2-基)硫)乙酰胺类化合物的合成及杀菌活性
Synthesis and fungicidal activity of novel N-aryl-2-((5-((4,6- dimethylpyrimidin-2-yl)thiomethyl)-1,3,4-thiadiazole- 2-yl)thio)-acetamide compounds
摘要
Abstract
In order to discover novel heterocyclic compounds with biological activities, ten novel N-aryl-2-((5-((4,6-dimethylpyrimidin-2-yl)thiomethyl)-1,3,4-thiadiazole-2-yl)thio)acetamide compounds were synthesized under microwave assisted condition via cyclization, esterification, hydrazination, cyclization and the condensation reactions. The structures of the title compounds were characterized by 1H NMR, 13C NMR, IR, ESI-MS and elemental analysis. The preliminary bioassay results indicated that most of them showed inhibition activity against Colletotrichum orbiculare, Botrytis cinerea and Rhizoctonia solani at the concentration of 50 mg/L. The inhibition rate of compound 8h against C. orbiculare reached 77.3%.关键词
N-芳基-2-((5-((4,6-二甲基嘧啶-2-基)硫甲基)-1,3,4-噻二唑-2-基)硫)乙酰胺/微波辅助合成/杀菌活性Key words
N-aryl-2-((5-((4/6-dimethylpyrimidin-2-yl)thiomethyl)-1/3/4-thiadiazole-2-yl)thio)acet-amide/microwave assisted synthesis/fungicidal activity分类
化学化工引用本文复制引用
汪聿清,李倩梅,温亚龙,谭成侠,邢家华,翁建全..新型N-芳基-2-((5-((4,6-二甲基嘧啶-2-基)硫甲基)-1,3,4-噻二唑-2-基)硫)乙酰胺类化合物的合成及杀菌活性[J].农药学学报,2017,19(2):162-168,7.基金项目
国家自然科学基金(30900959) （30900959）
浙江省自然科学基金(LY17C140003)资助项目. （LY17C140003）
