农药学学报2017，Vol.19Issue(2)：169-175,7.DOI:10.16801/j.issn.1008-7303.2017.0022
2-吡啶酰氨基环己烷基磺酰胺的合成与杀菌活性
Synthesis and fungicidal activity of 2-pyridinecarboxamide cyclohexylsulfonamides
摘要
Abstract
In order to explore the fungicidal activity and structure-activity relationship of cycloalkylsulfonamides, 152-pyridinecarboxamide cyclohexylsulfonamides were synthesized and their activities against Botrytis cinerea were tested by in vitro mycelial growth rate method and in vivo leaf method. The title compounds were designed and synthesized by the reaction between pyridine formyl chloride and 2-amino cyclohexylsulfonamides, which was obtained from the reduction amination reaction using 2-oxocyclohexenylsulfonamides as the starting materials. The bioassay exhibited that all the compounds possessed fungicidal activities against B. cinerea and other five phytopathogenic fungi. Notably, compound V-8 showed good activity with the EC50 value of 1.41 mg/L in vitro and the control efficiency of 79.17% in vivo against B. cinerea. Moreover, some of these compounds exhibited the inhibition rate of more than 60% against Rhizoctonia solani Kühn, Pyricularia grisea, Pythium aphanidermatum, Fusarium oxysporium and Phytophthora capsici. Compound V-7, with the EC50 value of 2.7 mg/L, showed better activity than carbendazim (with the EC50 value of 4.4 mg/L) against Pythium aphanidermatum. These promising compounds had great potentials for further research.关键词
2-氨基环己烷基磺酰胺/取代吡啶酰胺/灰霉病菌/杀菌活性/构效关系Key words
2-aminocyclohexylsulfonamides/substituted pyridinecarboxamide/Botrytis cinerea/fungicidal activity/structure-activity relationship分类
化学化工引用本文复制引用
王闽龙,曲圣极,纪明山,祁之秋,李兴海..2-吡啶酰氨基环己烷基磺酰胺的合成与杀菌活性[J].农药学学报,2017,19(2):169-175,7.基金项目
辽宁省自然科学基金(2015020766) （2015020766）
辽宁省教育厅科学研究项目(LJNYB201611) （LJNYB201611）
国家自然科学基金(31101466). （31101466）
