青岛大学医学院学报2017，Vol.53Issue(1)：5-7,11,4.DOI:10.13361/j.qdyxy.201701002
XE991对6-OHDA诱导帕金森病模型大鼠运动行为影响
EFFECTS OF XE991 ON MOTOR BEHAVIOR IN 6-OHDA-INDUCED PARKINSON'S DISEASE RAT MODELS
摘要
Abstract
Objective To investigate the effect of KCNQ channel inhibitor (XE991) on motor behavior of model rats in 6-OHDA-induced Parkinson's disease (PD).Methods Forty-eight male adult Wistar rats were divided into three groups-control group,6-OHDA group and XE991 + 6-OHDA group-in random.Using stereotaxic technology,the rats in 6-OHDA group were injected with 6-OHDA into the forebrain bundle of the midbrain to create a PD model.The rats in 6-OHDA-XE991 group were microinjection with XE991 (10 μmol/L,i.c.v.),into lateral ventricle at the same time of 6-OHDA administration,and those in the control group were given equal amount of normal saline to replace 6-OHDA and XE991.The changes in rotational behavior induced by apomorphine (APO) were detected in rats of the three groups-on days 7 and 14 of the experiment.Results On days 7 and 14 after the experiment,the number of turns in rats of 6-OHDA group was obviously higher than that of the control group (F =341.345,105.698;q =24.307,14.465;P＜0.01).Lateral ventricle injection of XE991 can significantly improve the above rotation behavior induced by 6-OHDA,the difference being significant (q=20.270,9.354;P＜0.01).Conclusion XE991 may improve motor ability of 6-OHDA-induced Parkinson's disease model rats.关键词
10,10二(4-吡啶甲基)-9(10H)-蒽酮/羟多巴胺/帕金森病/KCNQ钾通道/重复测量方差分析Key words
10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone/oxidopamine/Parkinson disease/KCNQ potassium channels/repeated measurement ANOV分类
医药卫生引用本文复制引用
刘海霞,陈小燕,薛宝,石丽敏,谢俊霞..XE991对6-OHDA诱导帕金森病模型大鼠运动行为影响[J].青岛大学医学院学报,2017,53(1):5-7,11,4.基金项目
国家自然科学基金项目(81430024,31671054),青岛市科技成果转化引导计划(青年专项)项目(14-2-4-72-jch). （81430024,31671054）
