摘要
Abstract
Objective To explore the differences in onset characteristics of primary gout between male and female.Methods Clinical data of 1 633 patients with primary gout-who came to our clinic to see a doctor during January 2011 September 2016-were collected.Among them,1 279 were men and 354 women.Clinical characteristics-such as age,BMI,family history of gout,blood biochemistry,and the first incidence site and the.detection rate of gout stones,kidney stones,coronary heart disease and hypertension between male and female patients were compared.Results The age of onset of gout in female was greater than that in male,the difference was statistically significant (t=3.450,P ＜0.05).The proportion of onset after 55 years old was 72％ in women,and showed a rising trend with the growth of age,and that was 28％ in men,showing a declining trend with age.The levels of uric acid in female patients were lower than that in male patients (t=9.997,P ＜0.05).The proportion of BMI and overweight or obese female patients were lower than that in male patients (t =6.078,x 2 =12.428,P＜0.05).In female,the detection rates of tophi and renal stone were lower than that in male,while that of coronary heart disease and hypertension were higher (x2 =6.068,13.988;P＜0.05).The proportion of habitual drinking and chronic smoking was higher in male patients than that in female (x2 =26.409,26.474;P＜0.05).As for positive family history,the proportion was higher in female patients (x2 =13.590,P＜0.05).The most common starting position of the onset was the first metatarsophalangeal joint,male were more than female,but the difference was not statistically significant (P＞0.05).In the female patients,the percentage of the first onset sites of wrist joint,finger joint and knee was higher as compared with the male (x2 =6.149-29.961,P＜0.05),and in the male,the percentage of dorsalis pedis being higher (x2-23.049,P＜0.05).Conclusion Age at onset of gout in women is obviously later than men,and there is a more significant familial genetic predisposition.Gouty tophi and renal stones are commonly seen in male patients with gout,and in female patients,concomitant coronary heart disease and hypertension are common.The difference in the initial joint involved of the onset of gout is significant between men and women-except for the first metatarsophalangeal joint.关键词
痛风/性别特性/疾病特征Key words
gout/gender identity/disease attributes分类
医药卫生
