日用化学工业（中英文）2017，Vol.47Issue(4)：212-218,7.DOI:10.13218/j.cnki.csdc.2017.04.007
包覆二氧化钛固体脂质微粒的制备研究
Preparation technology of solid lipid nanoparticles for encapsulation of nano-titanium dioxide
摘要
Abstract
Nano - TiO2 encapsulated with solid lipid nanoparticles was prepared by interface compound generation method,and the formulation was optimized. The influences of blending ratio of emulsifiers sodium stearoyl glutamate (SG)to fatty alcohol polyoxyethylene ether-21 (S21),as well as the mass fraction of solid lipid (docosanol)and liquid lipid (silicone oil 345)on quality and sunscreening performance of the product were studied. Results show that under conditions as:mass fraction of nano-TiO2 ,3%;total mass fraction of emulsifiers,8%(in which m (SG ): m (S21 )=2:1 );mass fraction of docosanol,4. 5%;mass fraction of silicone oil 345,4. 5%;average particle size of solid lipid nanoparticles encapsulated nano -TiO2 product achieves 219. 7 nm,and value of polydispersity index (PDI)achieves 0. 221. The system stability of the product is quite good. Comparison of the various influencing factors shows that,for a fixed mass fraction of nano-TiO2 ,the blending ratio of the emulsifiers as well as mass fraction of the liquid lipid displays rather big influence on UV absorption performance of the product,while that of solid lipid is not big.关键词
防晒剂/固体脂质微粒/纳米二氧化钛/包覆Key words
sunscreen/solid lipid nanoparticles/nano-TiO2/encapsulation分类
化学化工引用本文复制引用
李玲玉,张婉萍,张倩洁..包覆二氧化钛固体脂质微粒的制备研究[J].日用化学工业（中英文）,2017,47(4):212-218,7.基金项目
上海应用技术学院引进人才科研启动项目(YJ2016-22) （YJ2016-22）
