四川精神卫生2017，Vol.30Issue(2)：113-116,4.DOI:10.11886/j.issn.1007-3256.2017.02.005
住院抑郁症患者联合心境稳定剂治疗的影响因素研究
Clinical characteristics and influencing factors of mood stabilizer augmentation for the treatment of hospitalized patients with depressive disorder
摘要
Abstract
Objective To explore influencing factors of mood stabilizer (MS) augmentation for the treatment of hospitalized patients with depressive disorder by the analysis of the clinical characteristics, for providing evidences for clinical treatment.Methods A retrospective analysis was performed on clinical data of all 472 patients with depressive disorder who were admitted to Depression Treatment Center in Beijing Anding Hospital between December 2013 and November 2016.The data were concerned the demography and clinical characteristics to compare the differences between MS augmentation group and non-MS group.Results The proportion of MS augmentation was 8.3% (39/472).Compared to non-MS group, the characteristics of MS augmentation group were younger (Z=-4.435, P<0.01), more male (64.1% vs.37.6%, χ2=10.451, P<0.01), more single (41.0% vs.9.9%, χ2=9.460, P<0.01), inoccupation (38.5% vs.21.0%, χ2=6.253, P<0.05), age of onset under 18 years old (43.6% vs.7.2%, χ2=51.977, P<0.01), more treatment resistant depression (17.9% vs.4.6%,χ2=11.787, P<0.01), less anxiety features (23.1% vs.44.7%, χ2=6.813, P<0.01), more antipsychotics use (76.9% vs. 54.5%, χ2=7.311, P<0.01).Logistic regression analyses demonstrate that younger age (OR=0.9, 95%CI: 0.91~0.98, P<0.05), male gender (OR=2.4, 95% CI: 1.1~5.7, P<0.05), age of onset under 18 years old (OR=0.2, 95%CI: 0.05~0.4, P<0.01), treatment resistant depression (OR=4.9, 95%CI: 1.5~15.9, P<0.01), antipsychotics use(OR=2.4, 95%CI: 1.1~5.7, P<0.05) were influencing factors of MS augmentation.Conclusion Clinical psychiatrists tend to choose mood stabilizer augmentation for the treatment of hospitalized depressive patients with the characteristics of younger age, early onset of illness, male, treatment resistant depression and current antipsychotic use.关键词
抑郁症/心境稳定剂/临床特征/影响因素Key words
Depression/Mood stabilizer/Clinical characteristics/Influencing factors分类
医药卫生引用本文复制引用
赵茜,史晓宁,路亚洲,张玲..住院抑郁症患者联合心境稳定剂治疗的影响因素研究[J].四川精神卫生,2017,30(2):113-116,4.基金项目
国家"十二五"科技支撑计划(2015BAI13B03) （2015BAI13B03）
北京市科学技术委员会首都临床特色应用研究(Z141107002514033) （Z141107002514033）
