四川医学2017，Vol.38Issue(4)：398-401,4.DOI:10.16252/j.cnki.issn1004-0501-2017.04.011
帕瑞昔布钠静脉注射联合罗哌卡因切口浸润在经鼻蝶入路鞍区占位切除术后镇痛的临床研究
Intravenous Injection of Parecoxib Sodium Combined with Ropivacaine Incision Infiltration in TranssphenoidalSellar Tumor Resection in Post-operative Analgesia
赵玲 1刘丹彦 1杨刚1
作者信息
- 1. 宜宾市第二人民医院,四川 宜宾 644000
- 折叠
摘要
Abstract
Objective To observe the post-operative analgesia effect and safety of intravenous injection of parecoxib sodium combined with ropivacaine incision infiltration in transsphenoidalsellar tumor resection.Methods 80 cases of patients undergoing elective transsphenoidalsellar tumor resection were randomly divided into 4 groups(n=20) with a prospective,randomized,controlled and double-blind method.Group A received 10ml placebo for intravenous injection and 2ml placebo for local incision infiltration.Group p was treated with 40mg parecoxib sodium for intravenous injection and 2ml placebo for local incision infiltration.Group L were given 10ml placebo for intravenous and 2ml 1% ropivacainefor local incision infiltration.And group PL were treated with 40mg parecoxib sodium for intravenous injection and 2ml 1% ropivacaine for local incision infiltration.After operation,the VAS score at 6th hour,12th hour,24th hour,36th hour and 48th hour,analgesia satisfaction of patients and the number of patients with 2% lidocaine nasal drops for rescue analgesia were recorded.Adverse reaction including skin itching,nausea,vomiting,adverse cardiovascular events and local anesthetics poisoning were observed.Results TheVAS score within 24 hours of group A was higher than other three groups(P<0.05).The VAS score at 6th hour after operation of group PL was lower than that of Group P(P<0.05).The VAS score at 12th hour and 24th hour after operation of group PL were lower than those of Group L(P<0.05).There were no significant difference in side effect between group PL and other three groups(P>0.05).Conclusion It has an exact analgesia effect and safety to adopt intravenous injection of parecoxib sodium combined with ropivacaine incision infiltration in transsphenoidalsellar tumor resection.关键词
环氧化物酶2抑制剂/疼痛/手术后/镇痛Key words
cyclooxygenase 2 inhibitor/pain/postoperative/analgesia分类
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赵玲,刘丹彦,杨刚..帕瑞昔布钠静脉注射联合罗哌卡因切口浸润在经鼻蝶入路鞍区占位切除术后镇痛的临床研究[J].四川医学,2017,38(4):398-401,4.
