肿瘤预防与治疗2017，Vol.30Issue(2)：85-91,7.DOI:10.3969/j.issn.1674-0904.2017.02.004
经倾向指数匹配后手术切除合并辅助化疗和非手术治疗局限期小细胞肺癌的疗效比较
Effect Evaluation between Surgery with Adjuvant Chemotherapy and Non-operative Regimens in Treatment of Limited Disease Small Cell Lung Cancer based on Propensity Score Matching Method
摘要
Abstract
Objective: To evaluate the therapeutic effects of surgical resection combined with adjuvant chemotherapy in the patients with limited disease small cell lung cancer(LD-SCLC) based on propensity score matching.Methods: Between 2009 and 2014, 61 surgical resections and 96 non-operatives were performed on patients with disease limited stage small cell lung cancer in our institute.Pretreatment clinical parameters including T stage, N stage, number of lesions and histology were used for propensity score matching.After propensity score matching, 30 operative patients and 30 non-operative patients were selected and compared.Results: The median survival time of operative group was 27 months(95%CI:2.73-51.26), and the other group was 14 months(95%CI:11.8-16.18).After propensity matching, two groups were similar in regards to important variables.The long-term survival time was significant different (27 months vs.17 months, P=0.001).Conclusion: The current propensity score analysis suggests that surgical resection combined with adjuvant chemotherapy can benefit the survival of patients with limited disease small cell lung cancer.关键词
倾向指数/局限期小细胞肺癌/生存分析/手术治疗/辅助化疗Key words
Propensity score/Limited disease small cell lung cancer/Survival analysis/Operative/Adjuvant chemotherapy分类
医药卫生引用本文复制引用
潘辉,胡艺缤,郭志华,张亚雷,殷伟强,张晋昕..经倾向指数匹配后手术切除合并辅助化疗和非手术治疗局限期小细胞肺癌的疗效比较[J].肿瘤预防与治疗,2017,30(2):85-91,7.基金项目
广东省科技计划项目(编号:2014A020212713) （编号:2014A020212713）
