肿瘤预防与治疗2017，Vol.30Issue(2)：96-101,6.DOI:10.3969/j.issn.1674-0904.2017.02.006
肝动脉化疗栓塞同步联合多源微波消融治疗大肝癌的初步临床应用
Initial Clinical Application of Transcatheter Arterial Chemoembolization Synchronously Combined with Multiple Microwave Ablation in the Treatment of Large Hepatocellular Carcinoma
摘要
Abstract
Objective: To evaluate the safety and efficacy of transcatheter arterial chemoembolization (TACE) synchronously combined with multiple microwave ablation in the treatment of large hepatocellular carcinoma (HCC).Methods: Twenty-two patients diagnosed as large hepatocellular carcinoma (mean maximum diameter: 9.33±3.23cm) in our hospital between July 2015 and June 2016 were analyzed retrospectively.The procedures of TACE synchronously combined with multiple microwave ablation were carried out in all patients.Liver and renal function were examined before and after the treatment.The therapeutic effects were evaluated according to the mRECIST by 1-month follow-up magnetic resonance imaging (MRI).The t-test was used to compare quantitative variables.Progression-free survival (RFS) and overall survival (OS) rates were calculated by the Kaplan-Meier method.Results: Combined treatment was successfully achieved for all patients.The transient elevation of ALT, AST and TBil occurred within 3 days after the treatment.The level of ALB, CRE, and PT was not statistically significant different before and after the treatment (P>0.05).Patients had compli-cations after the treatment as pain in 15, fever in 1, pleural effusion in 6 and liver subcapsular hemorrhage in 1.MRI showed 8 cases with complete response and 14 cases with partial response 1 month after treatment.During the follow-up period (mean, 11.42±3.81 months), the 1-and 3-year PFS and OS rates were 32.3% and 74.4%, respectively.Conclusion: Transcatheter arterial chemoembolization synchronously combined with multiple microwave ablation is a safe and effective treatment for large hepatocellular carcinoma.关键词
大肝癌/肝动脉化疗栓塞/多源微波Key words
Large Hepatocellular Carcinoma/Transcatheter Arterial Chemoembolization/Multiple Microwave Ablation分类
医药卫生引用本文复制引用
黄森渺,张天奇,黄职妹,顾阳葵,高飞,陈桂群,黄金华..肝动脉化疗栓塞同步联合多源微波消融治疗大肝癌的初步临床应用[J].肿瘤预防与治疗,2017,30(2):96-101,6.基金项目
国家自然科学基金(编号:81371652) （编号:81371652）
中山大学临床医学研究5010计划项目(编号:2016002) （编号:2016002）
