肿瘤预防与治疗2017，Vol.30Issue(2)：102-106,120,6.DOI:10.3969/j.issn.1674-0904.2017.02.007
原发性前列腺恶性淋巴瘤11例诊治报道
Diagnoses and Treatment Reports of 11 Cases of Primary Malignant Lymphoma of Prostate
摘要
Abstract
Objective: To investigate the clinical features and prognosis of primary malignant lymphoma of the prostate (PMLP).Methods: From November 2005 to December 2016, clinical, diagnose and pathologic data of eleven patients from the Third Affiliated Hospital of Sun Yat-sen University, the First Affiliated Hospital of Sun Yat-sen University and the Affiliated Hospital of Pingdingshan University were collected for analysis.Results: Lymphoma tended to occur in an elderly patient, with a mean age at diagnosis of 68 years (range: 57~82 years).The average serum prostate-specific antigen(PSA) levels and lactate dehydrogenase (LDH) levels were 2.68ng/ml (range: 0.54~4.82ng/ml) and 314.9 U/L(123.0~560.0 U/L), respectively.Computed tomography (CT) imaging demonstrated a large mass in the prostate, as well as obvious low urinary tract symptoms (LUTS) resulting from infiltration of the mass.Histological findings revealed diffuse large B-cell non-Hodgkin's lymphoma, including nine cases with diffuse large B-cell lymphoma and two cases of mantle cell lymphoma.The median survival time was 28 months, (range: 9~62 months), with six patients died of malignant lymphoma.Of them, 10 patients underwent surgery, 6 of them underwent subsequent CHOP or R-CHOP chemotherapy and 50% (3 of 6) displayed a survival time over 56 months.Conclusion: PMLP is a rare prostatic malignancy involving the prostate, which displayed few specific characteristic signs on laboratory tests (i.e.PSA and LDH) and CT examination.However, patients with PMLP respond well to chemotherapy, and combined treatment with operative intervention should be taken into account as LUTS could be cured by surgery.关键词
淋巴瘤/前列腺/诊断/治疗Key words
Lymphoma/Prostate/Diagnoses/Treatment分类
医药卫生引用本文复制引用
陈征,李馨,王珏,潘宇航,梁琼,邵春奎,高新,庞俊..原发性前列腺恶性淋巴瘤11例诊治报道[J].肿瘤预防与治疗,2017,30(2):102-106,120,6.基金项目
广州市科技计划项目(编号201604020006) （编号201604020006）
