肿瘤预防与治疗2017，Vol.30Issue(2)：107-111,5.DOI:10.3969/j.issn.1674-0904.2017.02.008
HBsAg(-)HBcAb(+)肿瘤患者化疗后HBV再激活3例报道并文献复习
Reactivation of Hepatitis B Virus Infection after Chemotherapy in Cancer Patients with HBsAg(-)HBcAb(+) :Three Cases Reports and Literatures Review
罗皓 1周澄亚 1李力 1杨学刚 1杨溪霖 1吴立春1
作者信息
- 1. 四川省肿瘤医院·研究所,四川省癌症防治中心,电子科技大学医学院,成都 610041
- 折叠
摘要
Abstract
Objective: To study the treatment and management for hepatitis B virus(HBV) reactivation after chemotherapy in cancer patients with HBsAg(-)HBcAb(+).Methods: This study presented three different cases of HBV reactivation after chemotherapy, and made a literatures review about possible prophylactic and therapeutic methods.Results:One non-Hodgkin lymphoma(NHL)patient with HBsAb(+)HBcAb(+) changed into HBsAg(+)HBeAg(+)HBcAb(+) after several cycles of chemotherapy.In another Hodgkin's lymphoma(HL) patient with HBeAb(+)、HBcAb(+), the HBV-DNA level was elevated after chemotherapy.The last HBsAb(+), HBeAb(+), HBcAb(+) hepatocellular carcinoma patient's HBV-DNA level was also elevated after the transarterial chemoembolization(TACE).The three patients of HBsAg(-)suffered from HBV reactivation during the chemotherapy, but all of them obtained good outcome following the antiviral therapy.Conclusion: The HBsAg, liver function and HBV-DNA level should be closely monitored during the procedure of chemotherapy or immunosuppressive therapy not only in the patients of HBsAg (+),but also in the HBsAg(-)HBcAb(+) patients who once suffered from acute hepatitis or chronic hepatitis infection.If necessary, the prophylactic use of antiviral therapy should be carried out in case the unexpected stop of the treatment regimen.关键词
乙型肝炎病毒/再激活/肿瘤/化疗Key words
Hepatitis B Virus/Reactivation/Cancer/Chemotherapy分类
医药卫生引用本文复制引用
罗皓,周澄亚,李力,杨学刚,杨溪霖,吴立春..HBsAg(-)HBcAb(+)肿瘤患者化疗后HBV再激活3例报道并文献复习[J].肿瘤预防与治疗,2017,30(2):107-111,5.
