药学研究2017，Vol.36Issue(4)：187-194,8.DOI:10.13506/j.cnki.jpr.2017.04.001
新型γ-分泌酶调节剂SPI-1865的研发历程概述
An overview in research and development process of a novel γ-secretase modulator SPI-1865
摘要
Abstract
Alzheimer's disease is a progressive neurodegenerative disorder,which is lack of efficient treatment measures.The β-amyloid (Aβ) oligomers and senile plaques,which are the result of β-amyloid aggregation outside the brain neurons,are strongly implicated the pathogenesis of AD.γ-secretase,a key enzyme involved in generation of Aβ,is a potential target in the development of drugs for AD therapy.γ-secretase modulators(GSM) are highly selective and have broad application prospects.This article briefly reviewed the development process of a novel γ-secretase modulator SPI-1865,aiming at providing valuable information for development and structural modifications of related GSM.关键词
阿尔茨海默症/β淀粉样蛋白/γ-分泌酶/γ-分泌酶调节剂/SPI-1865Key words
Alzheimer's disease/β-amyloid/γ-secretase/γ-Secretase modulators/SPI-1865分类
医药卫生引用本文复制引用
吕薛,胡立宏..新型γ-分泌酶调节剂SPI-1865的研发历程概述[J].药学研究,2017,36(4):187-194,8.基金项目
国家自然科学基金项目(No.81561148011、No.81473110、No.81273397) （No.81561148011、No.81473110、No.81273397）
