药学研究2017，Vol.36Issue(4)：209-214,6.DOI:10.13506/j.cnki.jpr.2017.04.007
银模板法制备中空金纳米粒及其质量评价
Preparation of hollow gold nanoparticles by silver template method and its quality evaluation
摘要
Abstract
Objective To prepare and characterize a hollow gold nanoparticles for loading drugs.Methods Preparing silver nanoparticles as templates,chloroauric acid was reacted with silver nanoparticles to produce gold shells by template-engaged replacement reactions.Then gold wrapped on the surface of silver nanoparticles,and finally formed a kind of hollow structure.The study on the preparation of hollow gold nanoparticles was carried out by single factor investigation.The structure of hollow gold nanoparticles was observed by transmission electron microscopy,and the absorption by UV scanning was investigated.Photothermal transformation of the carrier was researched by in vitro photothermal transformation experiment.And MTT assay was used to investigate the cytotoxicity of the vector.Results The hollow gold nanoparticles had a particle size of 35~55 nm with a shell thickness of 4~6 nm.The maximum absorption wavelength was 750~800 nm.And the preparation had good photothermal conversion ability.Cytotoxicity study in vitro indicated that the hollow gold nanoparticles did not cause significant toxicities on the HDF cells.Conclusion The optimized hollow gold nanoparticles had better hollow structure,good photothermal conversion ability and smaller cototoxicity.关键词
中空金纳米粒/银模板/光热转化/细胞毒性Key words
Hollow gold nanoparticles/Silver template/Photothermal conversion/Cell toxicity分类
医药卫生引用本文复制引用
尤晨,李琳,杨文倩,沈雁,涂家生..银模板法制备中空金纳米粒及其质量评价[J].药学研究,2017,36(4):209-214,6.基金项目
国家自然科学基金(No.81501579) （No.81501579）
