山东医药2017，Vol.57Issue(9)：9-11,3.DOI:10.3969/j.issn.1002-266X.2017.09.003
非转移性结直肠癌组织中MMR的表达状态及意义
Expression of MMR in non-metastatic colorectal carcinoma
摘要
Abstract
Objective To investigate the expression and significance of mismatch repair gene (MMR) in non-metastatic colorectal tissues.Methods Totally 141 patients with non-metastatic colorectal cancer who underwent surgery were selected,and none of them received preoperative radiotherapy or chemotherapy.The expression of four MMR proteins (MLH1,MSH2,MSH6,PMS2) in postoperative pathological specimens were detected by routine pathological examination and immunohistochemistry.One or more of the four proteins were not expressed,namely,the MMR expression was deleted (dMMR),and the clinicopathological features of the patients with normal and dMMR colorectal cancer were compared.Results The deletion rates of MLH1,MSH2,MSH6 and PMS2 were 15.6％ (22/141),2.8％ (4/141),7.1％ (10/141),15.6％ (22/141),and the dMMR rate was 25.5％ (36/141) in patients with non-metastatic colorectal cancer.MMR expression was correlated with non-metastatic colorectal cancer patient's age,location,tumor size and pathological type (all P ＜ 0.05),and dMMR occurred more frequently in patients younger than 60 years,proximal,mucinous and large tumors (all P ＜ 0.05).Conclusion MMR expression is absent in non-metastatic colorectal cancer,and MMR status is helpful in predicting prognosis and guiding therapy.关键词
结直肠癌/锗配修复基因/微卫星不稳定性/染色体不稳定性Key words
colorectal carcinoma/mismatch repair/microsatellite instability/chromosomal instability分类
医药卫生引用本文复制引用
岳欣,胡均,王家仓..非转移性结直肠癌组织中MMR的表达状态及意义[J].山东医药,2017,57(9):9-11,3.基金项目
国家自然科学基金项目(81101870) （81101870）
天津市卫生局科技基金项目(2014KZ080). （2014KZ080）
