山东医药2017，Vol.57Issue(10)：5-7,3.DOI:10.3969/j.issn.1002-266X.2017.10.002
ErbB2基因rs1058808位点多态性与延边地区HBV相关肝细胞肝癌的关系及民族差异
Relationship of ErbB2 gene rs1058808 polymorphism with HBV-related hepatocellular carcinoma in Yanbian area and ethnic difference
摘要
Abstract
Objective To investigate the rs1058808 polymorphism of ErbB2 gene in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) in Yanbian area,and to explore the correlation between rs1058808 polymorphism and HBV-related HCC and ethnic differences.Methods The gene polymorphisms of rs1058808 in ErbB2 of 66 cases of patients with HBV associated HCC (the experimental group,including 28 cases of Korean nationality and 38 cases of Han nationality) and 150 cases of pure HBV carriers (the control group,including 68 cases of Korean nationality and 82 cases of Han nationality) were detected by dideoxy chain-termination method.We analyzed the genotype and allele distribution in the two groups.Results Both the two groups had rs1058808 ErbB2 gene loci of CC,CG and GG genotypes,and G gene was the most allele.The proportions of CC,CG and GG genotypes of ErbB2 gene rs1058808 loci in the experimental group were 15.2％,46.9％ and 15.2％,while in the control group they were 14.7％,62.7％ and 22.7％;the proportion of GG genotype in the experimental group was higher than that of the control group (P ＜0.01).The proportions of rs1058808 ErbB2 gene loci GG genotype in the Korean nationality and Han nationality of the experimental group were 35.7％,36.8％,which were higher than those of the control group (23.5％,22.0％)(all P ＜0.01).There was no statistically significant difference between the two national groups in CC,CG genotypes,C and G allele distribution.In the experimental group,there was no statistically significant difference in CC,CG and GG genotypes and C and G allele distribution between Han and Korean patients (all P＞0.05).Conclusion The GG genotype of rs1058808 in ErbB2 may be the main genetic risk factor for HBV-associated HCC in Yanbian area,and there is no national differences between Han and Chinese-Korean patients.关键词
肝细胞肝癌/ErbB2/基因多态性/乙型肝炎病毒/民族差异/延边Key words
hepatocellular carcinoma/ErbB2/gene polymorphism/hepatitis B virus/ethnic difference/Yanbian area分类
医药卫生引用本文复制引用
崔文豪,李成浩,朴熙绪,许东元,刘兰..ErbB2基因rs1058808位点多态性与延边地区HBV相关肝细胞肝癌的关系及民族差异[J].山东医药,2017,57(10):5-7,3.基金项目
国家自然科学基金资助项目(81560400) （81560400）
吉林省教育厅“十二五”科学技术研究项目(2013-13). （2013-13）
