山东医药2017，Vol.57Issue(16)：12-15,4.DOI:10.3969/j.issn.1002-266X.2017.16.004
钛合金假体表面涂层微孔孔径和孔隙率对骨整合的影响
Effect of porous coating of titanium alloy prosthesis with different pore size and porosity on osseointegration
摘要
Abstract
Objective To study the effect of porous coating of titanium alloy prosthesis with different pore size and porosity on osseointegration.Methods Three kinds of titanium alloy prosthesis with different porous surface were manufactured by 3D printing technology.The micropore diameter and the porosity was (260.5±34.5) μm and 68.1% in type a, (553.2±16.7) μm and 79.2% in type b, and (749.8±15.0) μm and 89.0% in type c.Twenty-seven New Zealand white rabbits were randomly divided into three groups, which were group A, group B and group C, and three kinds of prostheses were implanted into the femoral medullary cavity of rabbits.Three rabbits of each group were randomly sacrificed at the end of the fourth, eighth, twelfth weeks after operation.Micro-CT were taken to observe the condition of bone formation of each group, while bone volume fraction (BV/TV) and tissue mineral density (TMD) were measured by Micro-CT, the peak pull-out load of each group was measured by pull-out testing.Results At the fourth week after operation, all of the prostheses were in good position, the area within and around pores showed low signal, and no obvious bone formation was found.Distal parts of prostheses were only covered by little immature osteoid, but most of it was fibrous connective tissue and oboslete blood clot which could be washed away easily.The BV/TV, TMD and peak of pull-out load showed no statistical difference between any two groups (all P>0.05).At the eighth week after operation, the area within and around pores showed medium signal, which was immaturate osteoid, and especially in the group A, which was more than the other two groups.Distal pull-out specimens were all covered by bone in the three groups, and the middle of prostheses of group A also showed bone deposition.The BV/TV and TMD showed no statistical difference between any two groups, but the peak pull-out load of group A was higher than that of group B and group C (all P<0.05).At the twelfth week after operation, the area within and around pores all appeared high density shadow, which was bone deposition, and formed locking junction in three dimension, group A was more than group B and group C, no obvious osteolysis was found.All the parts of prostheses of group A were evenly covered by a lot of bone, the distal and proximal prostheses of group B and group C appeared significant bone formation, but less than that of group A.The BV/TV and TMD of group A was significant higher than that of group B and group C (P<0.05), the peak pull-out load showed statistical difference between every two groups (all P<0.05), and the sequence from high to low was: group A, group B, and group C.Conclusion The porous coating of titanium alloy prosthesis with pore size of 226-295 μm and porosity of 68.1% is the best for enhancing osseointegration, which shows good biomechanical property.关键词
全髋关节置换/人工假体/关节假体深层/微孔/骨整合/3D打印技术/兔Key words
total hip arthroplasty/artificial prosthesis/joint prosthesis coating/micropore/osseointegration/3D printing technology/rabbits分类
医药卫生引用本文复制引用
周鹏,赵辉,吴宇黎,吴海山,陈宜,丁喆如..钛合金假体表面涂层微孔孔径和孔隙率对骨整合的影响[J].山东医药,2017,57(16):12-15,4.基金项目
上海市教育委员会科研创新项目(15ZZ039). （15ZZ039）
