沈阳大学学报（自然科学版）2017，Vol.29Issue(2)：87-90,4.
载阿霉素的叶酸偶联羧甲基壳聚糖自组装纳米粒的研制及体外释放
Doxorubicin Loaded Folate Modified Carboxymethyl Chitosan Self-Assembled Nanoparticles and in Vitro Release
摘要
Abstract
Folate (FA) modified carboxymethyl chitosan (FCC) has been synthesized by chemical crosslinking method, and doxorubicin (DOX) loaded FCC nanoparticles (NPs) were prepared by self-assembly, which has the ability of targeting the tumor cells.Results showed that the nanoparticles were spherical and the particle size was about 200 nm.The drug loading content (DLC) and encapsulation efficiency (EE) were both affected by the adding DOX.The in vitro release showed that the NPs had a good pH-sensitive and sustained release for DOX.FA could enhance the DOX enrichment in the tumor cells, and reduce the toxicity for the normal tissues, which could improve the therapeutic effect of the tumor.关键词
叶酸/羧甲基壳聚糖/阿霉素/纳米粒/自组装Key words
folate/carboxymethyl chitosan/doxorubicin/nanoparticle/self-assembly分类
医药卫生引用本文复制引用
张岩,李长鸣,祁瑞艳,张梦茹,李迪..载阿霉素的叶酸偶联羧甲基壳聚糖自组装纳米粒的研制及体外释放[J].沈阳大学学报（自然科学版）,2017,29(2):87-90,4.基金项目
国家自然科学基金资助项目(81503014). （81503014）
