实验动物与比较医学2017，Vol.37Issue(2)：144-149,6.DOI:10.3969/j.issn.1674-5817.2017.02.012
生化标记方法在KM小鼠遗传结构分析中的应用
Application of Biochemical Markers on Analysis of Population Genetic Structure in KM mice
王洪 1魏杰 1李晓波 1巩薇 1岳秉飞1
作者信息
- 1. 中国食品药品检定研究院,北京100050
- 折叠
摘要
Abstract
Objective To analyze the change of genetic structure of KM mice colonies between 1990 and 2010.Methods KM mice colonies (18 mice in 1990 and 50 mice in 2010) were monitored by biochemical markers under instruction of national standard GB/T 14927.1-2008.POPGENE 1.32 software was used to process the data.Results In 1990,average heterozygosity is 0.262 5,polymorphism information content is 0.206 5.In 2010,average heterozygosity is 0.161 5,polymorphism information content is 0.130 7.By compared with the two colonies,population differentiation coefficient is 0.122 4 and the genetic distance is 0.095 1.Conclusion After 20 years outdred,the KM colony has medium change of population differentiation,but still be considered as same strain from the point of population genetics.关键词
KM小鼠/遗传结构/生化标记Key words
KM mice/Genetic structure/Biochemical markers分类
生物科学引用本文复制引用
王洪,魏杰,李晓波,巩薇,岳秉飞..生化标记方法在KM小鼠遗传结构分析中的应用[J].实验动物与比较医学,2017,37(2):144-149,6.
