上海针灸杂志2017，Vol.36Issue(5)：614-619,6.DOI:10.13460/j.issn.1005-0957.2017.05.0614
电针对不同月龄APP/PS1转基因小鼠行为学的影响
Effect of Electroacupuncture on the Behavior of APP/PS1 Transgenic Mice of Different Age
摘要
Abstract
Objective To study the effect of electroacupuncture on the behavior of APP/PS1 transgenic mice of different age, and to explore the optimal intervention time of electroacupuncture in treating Alzheimer's disease (AD). Method APP/PS1 double-transgenic mice of 4 months, 6 months and 9 months old, 20 in each age group, were randomized into a model group and an electroacupuncture group, and ten C57BL/6 wild-type mice were taken as a control group; after 6-week electroacupuncture treatment, the Morris water maze was adopted for spatial memory and behavioral test, and the changes of behavior in each group were observed.Result Of the 5-month-old mice, there were no significant between-group differences (P>0.05), while the time factor (day) produced a statistical significance (P<0.01); of the 7-month-old mice, there were significant differences considering the different groups, time factor and interaction (P<0.01); of the 10-month-old mice, there were significant differences considering the different groups, time factor and interaction (P<0.05). The spatial probe test showed that there were significant between-group differences in comparing the platform crossings and swimming distance in platform quadrant in each age group (P<0.05).Conclusion Electroacupuncture can improve the learning and memory of APP/PS1 double-transgenic mice, the age of 6-7 months old is possibly the optimal intervention time of electroacupuncture for AD, but there still requires further mechanism studies.关键词
电针/阿尔茨海默病/行为学测试/Morris水迷宫/APP/PS1转基因小鼠Key words
Electroacupuncture/Alzheimer disease/Behavior rating scale/Morris water maze/APP/PS1 transgenic mice分类
医药卫生引用本文复制引用
王鑫,李志刚,许安萍,曹瑾,卢梦晗,吕威,景泉凯,高扬,高誉姗,薛卫国..电针对不同月龄APP/PS1转基因小鼠行为学的影响[J].上海针灸杂志,2017,36(5):614-619,6.基金项目
国家自然科学基金项目(81273826,81273825) （81273826,81273825）
