生物技术通报2017，Vol.33Issue(5)：26-33,8.DOI:10.13560/j.cnki.biotech.bull.1985.2017.05.004
半胱氨酸参与生物体重金属抗性的研究进展
Research Progress on Cysteine Participation in Heavy Metal Resistance in Organism
摘要
Abstract
Cysteine(Cys),the final product of the sulfate assimilation pathway,widely exists in the organism. The oxidation state sulfur is absorbed and restored,and then integrated into the molecules skeletal structure of cysteine by organisms,participating in the other metabolic pathways of organisms. Because the structure of Cys contains thiol,which makes it being able to specifically bind with heavy metal ion,thus involving in the heavy metal resistance of organism,directly or indirectly. Considering a series of physiological and biochemical process in biological cells are orderly conducted under the heterogeneous condition,the investigation of Cys and the structure characteristics of Cys-M(M represents metal ion)complexes has significant reference value for studying Cys and the physiological behavior of Cys-M at the molecular level. In recent years,the application of new technique in the biological science,for example atomic force microscope(AFM), makes this research feasible. In this paper,the basic characteristics and the biosynthetic pathway of Cys are introduced,concurrently,the research progress of Cys involved in heavy metal resistance are summarized,which aims to provide certain scientific theoretical basis for studying the detoxification mechanism of Cys in heavy metal resistance of organism.关键词
半胱氨酸/生物合成途径/重金属抗性Key words
cysteine/biosynthetic pathway/heavy metal resistance引用本文复制引用
张礼,孙堆,王晓,郑春丽..半胱氨酸参与生物体重金属抗性的研究进展[J].生物技术通报,2017,33(5):26-33,8.基金项目
国家自然科学基金项目(51264029,41561094),内蒙古自治区青年科技英才计划项目(NJYT-14-B12),内蒙古自治区应用技术研究与开发资金项目,内蒙古科技大学创新基金(2014QNGG05) （51264029,41561094）
