生物技术通报2017，Vol.33Issue(5)：159-163,5.DOI:10.13560/j.cnki.biotech.bull.1985.2016-0953
潞党参多糖对宫颈癌细胞SiHa增殖和迁移的影响
Effects of Polysaccharides from Lu Dangshen(Codonopsis pilosula) on Proliferation and Migration of Human Cervical SiHa
摘要
Abstract
The effects of polysaccharides from Lu Dangshen(Codonopsis pilosula)(LDP)on the proliferation and migration of human cervical cancer cell SiHa was investigated. MTT method was used to determine the effects of LDP on SiHa cell proliferation,and cell adhesion assay,cell spreading assay and cell wound scratch assay were used to analyze the effect of LDP on SiHa cell migration. LDP significantly repressed SiHa cell proliferation(IC50 = 0.68 mg/mL),and inhibited adhesion between cells and extracellular matrix,and delayed cell spreading,and then restrained SiHa cell migration. LDP presents solid inhibition effects on the proliferation,adhesion,spreading and migration of human cervical cancer cell SiHa,and thus possesses potential value for developing auxiliary medicine for tumor treatment and dietary supplement.关键词
潞党参多糖(LuDangshenpolysaccharides,LDP)/细胞增殖/细胞黏附/细胞铺展/细胞迁移Key words
polysaccharides from Lu Dangshen(Codonopsis pilosula)/cell proliferation/cell adhesion/cell spreading/cell migration引用本文复制引用
胡建燃,李平,雷海英,刘贤瑞..潞党参多糖对宫颈癌细胞SiHa增殖和迁移的影响[J].生物技术通报,2017,33(5):159-163,5.基金项目
山西省重点学科建设经省资助("服务产业创新学科群"培育项目),山西省高校创新学科群项目子项目(XKQZXM200601) （"服务产业创新学科群"培育项目）
