生殖医学杂志2017，Vol.26Issue(5)：418-422,5.DOI:10.3969/j.issn.1004-3845.2017.05.006
复发性滋养细胞肿瘤预后因素分析
Analysis of prognostic factors for relapsed gestational trophoblastic neoplasia
摘要
Abstract
Objective:To analyze retrospectively the prognosis factors of replased gestational trophoblastic neoplasia (GTN) in order to provide clinical reference for the patients' treatment.Methods:The patients with gestational trophoblastic neoplasia who had recurrence at least once and followed-up in Peking Union Medical College Hospital from January 1995 to December 2013 were included in the study.The following variables were assessed as potential prognostic factors of relapse in univariate and multivariate (Cox model) analysis:age,antecedent pregnancy,FIGO staging and score,initial serum β-HCG level,type of the first preoperative chemotherapy,chemotherapy course,etc.Results:Eighty six patients were included in the study,and 84.9% (73/86) of the relapsed patients achieved serous complete remission (SCR).The results of univariate analysis showed that the primary relapse occurred in the other hospitals (73±3.2 vs.130±31 months,χ2=4.792 P=0.038) and the first recurrence time≤3 months (69±10.4 vs.79±6.7 months,χ2=4.021 P=0.045) were the important prognosis factors of re-recurrence.Multivariate analysis showed that age≥31 years (χ2=3.897,P=0.048;95%CI:0.268~0.995) and the primary relapse occurred in the other hospitals (χ2=5.042,P=0.025;95%CI:0.168~0.886) were the important prognosis factors of re-recurrence.Conclusions:The most patients with relapsed gestational trophoblastic neoplasia can be cured by combined treatment with chemotherapy,surgery and radiotherapy,but novel therapies are required for the refractory patients.关键词
滋养细胞肿瘤/复发/预后Key words
Gestational trophoblastic neoplasia/Relapse/Prognosis引用本文复制引用
赵静,任彤,杨隽钧,冯凤芝,万希润,向阳..复发性滋养细胞肿瘤预后因素分析[J].生殖医学杂志,2017,26(5):418-422,5.基金项目
国家自然科学基金项目(81272890) （81272890）
中国博士后面上基金项目(2012M510354) （2012M510354）
