生殖医学杂志2017，Vol.26Issue(5)：423-427,5.DOI:10.3969/j.issn.1004-3845.2017.05.007
基础甲状腺功能与IVF-ET妊娠结局的相关性研究
Basic thyroid function and pregnancy outcome in IVF-ET
摘要
Abstract
Objective:To study the relationship between basic thyroid function and pregnancy outcome in IVF-ET.Methods:A total of 486 women with normal basic thyroid function who underwent the initial IVF/ICSI-ET treatment by using the long GnRH agonist protocol were included in our hospital from September 2014 to May 2015.The levels of thyroid stimulating hormone (TSH),free triiodothyronine (FT3) and free tetraiodothyronine (FT4) in fasting blood in menstruation 2nd to 4th day before IVF were measured.The relationship between basic thyroid function and IVF/ICSI pregnancy outcome were analyzed.Results:There were 305 clinical pregnancies,249 live births,and 23 early spontaneous abortions in 486 patients.There were no significant differences in serum TSH,FT3,FT4 levels between the clinical pregnant group and the non-pregnant group (P>0.05).The women were younger in the clinical pregnancy group (29.4±3.9 vs.30.7±4.3 years,P=0.001),and the endometrial thickness was thicker (11.0±2.2 vs.9.9±1.9 mm,P<0.001).And there were no significant differences in the TSH,FT3 and FT4 levels between the live birth group and spontaneous abortion group (P>0.05).Furthermore,there were no significant differences in clinical pregnancy rate,live birth rate,spontaneous abortion rate and neonatal birth weight between basic TSH≥2.5 mIU/L group and TSH<2.5 mIU/L group (P>0.05).Conclusions:The basic serum levels of TSH,FT3,FT4 in the normal range does not affect IVF/ICSI pregnancy outcome,while TSH≥2.5 mIU/L but<4.2 mIU/L does not increase spontaneous abortion rate or affect neonatal birth weight.关键词
甲状腺功能/促甲状腺激素/体外受精/卵胞浆内单精子注射/妊娠结局Key words
Thyroid function/Thyroid stimulating hormone/IVF/ICSI-ET/Pregnancy outcomes引用本文复制引用
刘蓉,孙海翔,周建军..基础甲状腺功能与IVF-ET妊娠结局的相关性研究[J].生殖医学杂志,2017,26(5):423-427,5.基金项目
国家自然科学基金面上项目(81571504) （81571504）
