生殖医学杂志2017，Vol.26Issue(5)：438-441,4.DOI:10.3969/j.issn.1004-3845.2017.05.010
重组生长激素应用于IVF前次失败患者的初步探讨
A pilot study of recombinant growth hormone used in patients with previous IVF failure
摘要
Abstract
Objective:To explore the effect of pretreatment with growth hormone (GH) on improvement of embryos quality in patients with previous IVF failure.Methods:Thirty six patients who had pregnancy failure due to no available embryo or poor quality of embryo in the previous cycle with long program or antagonist program were included in this study in Northwest Women's and Children's Hospital ART center from January 2015 to May 2016.The patients were received GH pretreatment for 4 to 6 weeks before ovulation induction,and continuously administrated with initial dose of GH to HCG day during the ovulation period,finally received the routine IVF or ICSI procedure after oocyte retrieval in the second cycle.The number of oocytes retrieved,fertilization rate,embryonic development and clinical pregnancy rate were compared between the two groups.Results:There were no significant differences in the total doses of gonadotropin (Gn),the days of ovulation induction,the endometrial thickness,the number of oocytes retrieved and the cancellation cycle rate between the two groups (P>0.05).The progesterone levels in GH cycle [(3.31±1.46) nmol/L] were significantly lower than those in control group [(2.51±1.14) nmol/L] (P<0.05).There was no significant difference in the fertilization rate and the rate of no available embryo for transplantation between the two groups (P>0.05).The 2PN rate (67.48% vs.53.50%),and the available embryo rate (72.04% vs.38.26%),the optimal embryo rate (30.11% vs.15.44%) and the clinical pregnancy rate (43.48% vs.0%) significantly higher than those in the control cycles (P<0.05).Conclusions:The patients with pregnancy failure due to poor quality of embryos in the previous IVF cycle were received the pretreatment with human growth hormone prior to ovulation induction can improve embryo quality and clinical pregnancy rate,but its specific mechanism and application effect still need further study.关键词
生长激素/预处理/IVF/胚胎质量Key words
Growth hormone/Pretreatment/IVF/Embryo quality引用本文复制引用
田莉,马淳,周寒鹰,刘茜桐,王婷,师娟子..重组生长激素应用于IVF前次失败患者的初步探讨[J].生殖医学杂志,2017,26(5):438-441,4.基金项目
陕西省卫生厅扶植项目(2012D44) （2012D44）
