王含必 1汤鲜 1温晓晓 1刘美芝 1张颖 1邓成艳1
作者信息
- 1. 中国医学科学院 北京协和医学院 北京协和医院妇产科,北京 100730
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摘要
Abstract
Objective:To explore the predictive value of follicular output rate (FORT) in IVF-ET cycle in the patients with hypogonadotropic hypogonadism (HH).Methods:A total of 60 IVF-ET cycles in 40 HH patients were studied.The cycles were divided into three groups according the FORT value:low (<50%),medium (100%>FORT≥50%) and high (≥100%) FORT groups.The clinical and laboratory parameters of controlled ovarian hyperstimulation and IVF-ET in the three groups were retrospectively analyzed.Results:The antral follicle count was increased progressively from low to the high FORT group (7.1±2.7,9.6±5.3 and 10.7±5.4,respectively,P<0.05).The total dosage and days of gonadotropin used were not significantly different among the three groups (P>0.05).However,The serum E2 levels on HCG day (12 918.77±7 472.12,9 716.33±5 872.00,6 556.82±3 780.83 pmol/L,respectively),the number of follicles before ovulation (8.7±2.6,6.9±2.9,4.9±2.3,respectively),the number of oocytes retrieved (9.3±3.8,7.8±3.3,6.5±3.0,respectively) and number of MII oocytes (7.8±4.2,6.3±3.2,5.4±2.5,respectively) were significantly higher in the high FORT group than those in other two groups (all P<0.05).There were no differences in the number of high quality embryo,embryo implantation rate,number of frozen embryos,and clinical pregnancy rate in the three groups.Conclusions:Follicular output rate may be used as a qualitative reflector for reactivity of follicles to gonadotropin in IVF-ET cycle in HH patients.High FORT may have more chance of getting more maturation oocytes.The predictive effect on pregnancy outcome remains to be confirmed by a larger sample size关键词
卵泡输出率/下丘脑垂体性闭经/体外受精-胚胎移植/控制性超排卵/窦卵泡/卵巢反应性Key words
Follicular output rate/Hypogonadotropic hypogonadism amenorrhea/IVF-ET/Controlled ovarian hyperstimulation/Antral follicle/Ovarian response
