生殖医学杂志2017，Vol.26Issue(5)：457-463,7.DOI:10.3969/j.issn.1004-3845.2017.05.014
复方玄驹胶囊联合补佳乐治疗薄型子宫内膜的临床疗效研究
Efficacy of Xuanju capsule with progynova in treatment of thin endometrium
张素伟 1于月新2
作者信息
- 1. 锦州医科大学,锦州 121000
- 2. 中国人民解放军第202医院,沈阳 110000
- 折叠
摘要
Abstract
Objective:To explore the efficacy of Xuanju capsule combined with progynova in patients with thin endometrium in frozen embryo transfer (FET) cycle.Methods:A total of 130 patients who were cancelled the transplantation due to thin endometrium or failed to be pregnant after transfer and undergoing to another FET were recruited from Chinese PLA 202 hospital Between Jan.and Aug.2016.They were randomly divided into four groups by random number table.The patients were not given any drug in group A;the patients were given progynova orally (3 mg bid) until the day of embryo transfer in group B;the patients were given Xuanju capsule orally (3 pills tid) until the same day in group C;and the patients were given both progynova and Xuanju capsule (ditto) in group D.Endometrial thickness and hormone levels of patients were detected every week after treatment and gestation status were evaluated at 1 month after embryo transfer.The changes in endometrial thickness before and after treatment were stratified by age (≥35 years,<35 years) and infertility years (>2 years,≤2 years).Results:According to age stratification analysis,regardless of<35 years or≥35 years,the endometrial thickness of all the patients showed an increasing trend.The most significant change of endometrial thickness was found in group D,and the difference was significant between the groups (P<0.05).The endometrial thickness increased in the patients with infertile duration≤2 years was significantly higher than that in the patients with infertile duration>2 years (P<0.05) in the four groups.The clinical pregnancy rate of group D was significantly higher than that of group A (P=0.010).Binary logistic regression analysis found that age of<35 years and the number of transplanted embryos had a better predictive effect on the pregnancy rate in patients with thin endometrium.The E2 level and the number of transplanted embryos had a better predictive effect on pregnancy rate in group D.Conclusions:In the endometrial preparation process of FET cycle,Xuanju capsule combined with progynova can improve the endometrial thickness and endometrial receptivity,and increase the pregnancy rate.关键词
复方玄驹胶囊/补佳乐/薄型子宫内膜/冻融胚胎移植Key words
Xuanju capsule/Progynova/Thin endometrium/Frozen embryo transfer引用本文复制引用
张素伟,于月新..复方玄驹胶囊联合补佳乐治疗薄型子宫内膜的临床疗效研究[J].生殖医学杂志,2017,26(5):457-463,7.
