天津中医药2017，Vol.34Issue(5)：295-298,4.DOI:10.11656/j.issn.1672-1519.2017.05.03
Nrf2:糖尿病防治新领域
Nrf2:new field of Prevention and treatment of diabetes mellitus
摘要
Abstract
The incidence of diabetes increased year by year, and had become one of the serious diseases that endanger human health. Research showed that oxidative stress was closely related to diabetes. The transcription factor NF-E2 related factor 2 (Nrf2) is an important transcription factor in the regulation of redox balance, can combine the antioxidant response element (ARE), activate the Nrf2/ARE pathway, regulate the transcription of downstream protection protein genes, reduce the release of reactive oxygen species (ROS) and play the effects of antioxidant and anti-inflammatory. As the most important endogenous antioxidant stress factor, Nrf2 has become a new field in the prevention and treatment of diabetes. This paper reviewed the oxidative stress, Nrf2 and oxidative stress, as well as the relationship between Nrf2 and diabetes mellitus and its complications.关键词
Nrf2/氧化应激/糖尿病/并发症Key words
Nrf2/oxidative stress/diabetes mellitus/complications分类
医药卫生引用本文复制引用
孔畅,赵泉霖,宋振华,阴永辉..Nrf2:糖尿病防治新领域[J].天津中医药,2017,34(5):295-298,4.基金项目
国家自然科学基金(81503572) （81503572）
山东省自然科学基金(ZR2015HL107) （ZR2015HL107）
山东省中医药科技发展计划项目(2015-002). （2015-002）
