天然产物研究与开发2017，Vol.29Issue(3)：410-414,5.DOI:10.16333/j.1001-6880.2017.3.008
红树林放线菌Stremptmeces costaricanus SCSIO ZS0073抗菌活性次级代谢产物的研究
Antibacterial Secondary Metabolites Produced by Mangrove-derived Actinomycete Stremptmeces costaricanus SCSIO ZS0073
摘要
Abstract
An actinomycete strain Stremptmeces costaricanus SCSIO ZS0073 producing strongly-antibacterial metabolites was isolated from the soil collected in Hongsha park.Guided by antibacterial assay,its fermentation was isolated and purified by Silica gel column,Sephadex LH-20 and HPLC.Three compounds were obtained,which were identified as actinomycin D (1),actinomycin Xoβ (2) and fungichromin(3) by MS and NMR spectroscopic analysis.The output of actinomycin D was more than 300 mg/L,even under nonoptimized growth conditions.关键词
红树林放线菌/抗菌活性/次级代谢产物/放线菌素/制霉色基素Key words
mangorove-derived actinomycetes/antibacterial activity/secondary metabolites/actinomycins/fungichromin分类
化学化工引用本文复制引用
宋现芹,蒋鑫,孙建彬,张春燕,张云,卢来春,鞠建华..红树林放线菌Stremptmeces costaricanus SCSIO ZS0073抗菌活性次级代谢产物的研究[J].天然产物研究与开发,2017,29(3):410-414,5.基金项目
国家国际科技合作项目(2011DFA32540) （2011DFA32540）
