天然产物研究与开发2017，Vol.29Issue(3)：431-434,510,5.DOI:10.16333/j.1001-6880.2017.3.012
由色胺酮合成卤代Phaitanthrin A及其对DNA的切割作用
Synthesis and DNA-Cleavage Activities of Halogenated-Phaitanthrin A Based on Tryptanthrin
摘要
Abstract
Tryptanthrin and phaitanthrin A are active alkaloids derived from Strobilanthes cusia,Polygonum tinetorium L.,and Isatis tinctoria L.In this study,halogenated tryptanthrin of 8-bromo-tryptanthrin (1) and 8-iodine tryptanthrin (2) were used as substrate to synthesize 8-Br-Phaitanthrin A(3) and 8-I-Phaitanthrin A(4) under solvothermal conditions.The structures and chiral configuration of the synthesized compounds were determined by 1HNMR,13 CNMR and X-ray diffraction.Spectroscopy and gel electrophoresis had shown that compounds 3 and 4 had a strong cleavage action towards DNA.关键词
色胺酮/Phaitanthrin A/DNA切割Key words
tryptanthrin/phaitanthrin A/DNA cleavage分类
医药卫生引用本文复制引用
顾运琼,申文英,郭雪梅,黄国保,罗志辉,谭明雄..由色胺酮合成卤代Phaitanthrin A及其对DNA的切割作用[J].天然产物研究与开发,2017,29(3):431-434,510,5.基金项目
国家自然科学基金(21261025) （21261025）
广西师范大学药用资源化学与药物分子工程省部共建国家重点实验室开发课题(CMEMR2011-09,CMEMR2014-B08) （CMEMR2011-09,CMEMR2014-B08）
广西高校科学技术重点项目(ZD2014108) （ZD2014108）
广西高校农产品深加工与安全技术高水平创新团队及卓越学者计划 （）
