摘要
Abstract
Objective To explore the correlation between knee-joint synovial fluid and plasma adiponectin (APN) levels and chronic inflammation of RA.Methods 80 RA patients admitted to our hospital were selected to constitute an observation group,and the disease activity of RA in the observation group was determined according to DAS28 standard.Meanwhile,30 healthy persons received physical examination in our hospital during the corresponding period were selected to constitute a control group.The levels of synovial fluid and plasma APN in the two groups were determined by ELISA method.In addition,such indicators as CRP,RF,lipid metabolism,ESR,and Glu and BP were also determined to analyze the correlation between APN and the severity and chronic inflammation of RA.Results (1)The ESR and CRP in the observation group were higher than those in the control group,while the plasma was lower than that in the control group (P ＜ 0.05);(2)with the increase of DAS28 activity,the synovial fluid and plasma APN of RA patients decreased (P ＜ 0.05),the change trends of synovial fluid and plasma APN were consistent,and the levels of synovial fluid and APN were lower than those of the plasma;(3)the levels of the plasma,knee-joint synovial fluid and APN of RF-positive and anti-CCP antibody positive patients were lower than those of negative RA patients,but the contrast difference was not statistically significant (P ＞ 0.05);(4)the levels of the plasma,knee-joint synovial fluid and APN of RA patients were positively correlated with TG and negatively correlated with DAS28 score.Conclusion The levels of the knee-joint synovial fluid and plasma APN of RA patients are negatively correlated with the severity of RA,and may be used as an important approach for the targeted intervention of RA.关键词
类风湿/关节炎/滑液/脂联素/相关性Key words
RA/arthritis/synovial fluid/APN/severity分类
医药卫生
