微创医学2017，Vol.12Issue(2)：162-165,186,5.DOI:10.11864/j.issn.1673.2017.02.02
实时荧光定量PCR检测人脑胶质瘤、髓母细胞瘤中SAMD14的表达
Expression of SAMD14 in human glioma and medulloblastoma detected by quantitative real time PCR
摘要
Abstract
Objective To analyze the expression of SAMD 14 mRNA in human glioma and medulloblastoma,and to study their association with clinical features of glioma and medulloblastoma.Methods The expression of SAMD 14 mRNA was detected in 10 human normal brain tissues, 24 glioma tissues and 11 medulloblastoma tissues by qRT-PCR, then the relationship of their expression and clinical features were analyzed.Results The expression of SAMD 14 mRNA was lower in glioma and medulloblastoma tissues than in human normal brain tissues.The expression of SMAD14 mRNA was higher in glioma tissues than in medulloblastoma tissues(P<0.05).There is no significant difference between the expression of SMAD14 mRNA and clinical features(Sex, age, tumor diameter and KPS scores,etc).Conclusion The low expression of SAMD 14 were possibly related to tumorigenesis of glioma and medulloblastoma.关键词
胶质瘤/髓母细胞瘤/SAMD14/荧光定量PCRKey words
Glioma/Medulloblastoma/SAMD 14/qRT-PCR分类
医药卫生引用本文复制引用
龚范勇,葛盈盈,肖绍文..实时荧光定量PCR检测人脑胶质瘤、髓母细胞瘤中SAMD14的表达[J].微创医学,2017,12(2):162-165,186,5.基金项目
国家自然科学基金(编号:81460382 （）
81560408) （）
广西自然科学基金(编号:2014GXNSFAA118231 （）
2014GXNSFAA118089) （）
广西医科大学青年科学基金(编号:GXMUYSF201409) （编号:GXMUYSF201409）
