微创医学2017，Vol.12Issue(2)：201-203,3.DOI:10.11864/j.issn.1673.2017.02.12
纳米碳淋巴结示踪剂在肠镜结直肠癌根治术中的临床意义
Clinical significance of nano-carbon lymph tracer in curative colonoscopic resection for colorectal carcinomo
摘要
Abstract
Objective To explore the clinical significance of nano-carbon lymph tracer in curative colonoscopic resection for colorectal carcinomo.Methods Sixty-two patients with colorectal carcinoma were randomly divided into observation group and control group, 31 cases in each group.Patients in the control group were treated with curative colonoscopic resection for colorectal carcinomo.One day before operation, patients in the observation group were given mucosa multi-points injection of carbon nano-carbon tracer under colonoscopy, and then were underwent curative colonoscopic resection for colorectal carcinomo in the second day;the extent of lymph node dissection was enlarged according to the nano-carbon black stained lymph nodes.Postoperative lymph node biopsy were used as the gold standard, to evaluate the accuracy of nano-carbon tracer labeled black stained lymph node in predicting the positive lymph nodes, as well as the effect on the detection rate of positive lymph nodes.Results A total of 750 lymph nodes were detected in control group, pathologically confirmed 12 cases of lymph node positive patients, 61 positive lymph nodes;the total detection rate was 8.13%(61/750).A total of 869 lymph nodes were detected in observation group, 17 cases of lymph node positive patients, 96 positive lymph nodes;the total detection rate was 11.05%(96/869).Comparing the detection rate of positive lymph node in the two groups, the difference was statistically significant (P<0.05).Among the 96 pathological positive lymph nodes, 48 lymph nodes were black stained by nano-carbon tracer, the black stained rate was 50.0%(48/96).Nano-carbon tracer black stained lymph nodes in predicting the lymph node positive patients, the sensitivity was 64.7%, specificity 85.7%, accuracy 74.2%.Conclusions Preoperative nano-carbon tracer for sentinel lymph node dissection in colorectal carcinoma has a guiding significance in intraoperative lymph node dissection, which can improve the number of lymph node dissection and the detection rate of lymph node metastasis.关键词
结直肠癌/纳米碳/黏膜下注射/示踪/检出率Key words
Colorectal carcinoma/Nano-carbon/Submucosal injection/Tracer/Detection rate分类
医药卫生引用本文复制引用
植中敬,江志远,陈慕维,邵少慰,沓世念,吴登东..纳米碳淋巴结示踪剂在肠镜结直肠癌根治术中的临床意义[J].微创医学,2017,12(2):201-203,3.基金项目
广东省肇庆市科研立项项目(编号:2015040308) （编号:2015040308）
