中国动脉硬化杂志2017，Vol.25Issue(4)：355-359,5.
人冠状动脉粥样硬化病灶内CD40L水平与病灶结构变化的关系
Relationship between CD40L level and lesion structure in human coronary atherosclerotic lesions
摘要
Abstract
Aim To observe the structural changes of human coronary atherosclerotic lesions and the expression of CD40L and matrix metalloproteinase-9 (MMP-9) protein,and to explore the role of CD40/CD40L signaling in the development of human coronary atherosclerosis.Methods 60 cases of human coronary artery with different degrees of atherosclerosis were collected as experimental group,and 12 cases without pathological changes were as control group.HE staining was used to observe the histological structure of coronary artery in the two groups,and image analysis software was used to detect the related indexes of the lesion structure.The expression levels of CD40L and MMP-9 protein were detected by immunohistochemical staining.The relationship between the expression of CD40L and MMP-9 and the structural changes of atherosclerotic lesions were analyzed.Results The expression of CD40L protein was enhanced in all the atherosclerotic coronary artery,and it was mainly expressed in the foam cells of the plaques shoulder and bottom.Moreover,the expression level of MMP-9 protein in the lesion was increased and it was positively correlated with the CD40L expression and the lesion size especially the necrosis size.There was no correlation between the expression level of MMP-9 and the thickness of fibrous cap.The ratio of fibrous cap thickness to the maximum intimal thickness was decreased with the increase of MMP-9 level.Conclusions The expressions of CD40L and MMP-9 protein are significantly enhanced in the human coronary atherosclerotic lesions.CD40L may promote the expression of MMP-9,to strengthen the extracellular matrix decomposition in vascular lesions,so as to promote the development of lesions and the enlargement of necrotic foci,thus the stability of atherosclerotic lesions is decreased.关键词
冠状动脉粥样硬化/CD40L/基质金属蛋白酶9/病灶结构Key words
Coronary artery atherosclerosis/CD40L/Matrix metalloproteinase-9/Lesion structure分类
医药卫生引用本文复制引用
耿俊梅,万昌武,乐翠云,刘江金,王玉,黄江..人冠状动脉粥样硬化病灶内CD40L水平与病灶结构变化的关系[J].中国动脉硬化杂志,2017,25(4):355-359,5.基金项目
贵州省高校工程技术研究中心建设项目(黔科合KY字[2013]114) （黔科合KY字[2013]114）
