中国动脉硬化杂志2017，Vol.25Issue(4)：360-364,5.
间歇有氧运动上调自发性高血压大鼠血管肾上腺髓质素
Intermittent aerobic exercise up-regulated expression of adrenomedullin of spontaneous hypertensive rat's artery
李宏伟 1蓝蕊 1刘佩东1
作者信息
- 1. 赣南师范大学体育学院,江西省赣州市341000
- 折叠
摘要
Abstract
Aim To probe the effect of Intermittent aerobic exercise on Adrenomedullin (ADM) secretion of artery of spontaneous hypertensive rat (SHR),and investigate the mechanism of artery of exercise in the prevention and treatment of hypertension.Methods 30 SHR are separated into two groups:intermittent exercise group (IAE Group)and control group.The IAE group performs 8 weeks intermittent treadmill exercise and their blood pressure are measured before and after exercise by tail pressure of SHR,serum ADM is detected by enzyme linked immunosorbent assay.ADM is expressed in artery by immunohistochemistry.Quantification of specific-receptor activity modifying protein (RAMP2)and calcitonin receptor like receptor(CRLR) in artery ADM are detected by Westernblotting.Results Quantification of specific receptor ADM were significantly lower than control group(P＜0.05) and serum ADM in IAE group were significantly higher than control group(P＜0.05).The expression of ADM in artery was obviously stronger than control group.The quantity of RAMP2 and CRLR in artery were increased obviously (P＜0.05).Conclusion Intermittent aerobic exercise increases the expression of ADM in artery and their specific receptor RAMP2 and CRLR up regulation may be one of the mechanisms of lower SHR blood pressure.关键词
间歇有氧运动/自发性高血压大鼠/肾上腺髓质素/肾上腺髓质素特异性受体Key words
Intermittent aerobic exercise/Spontaneous hypertensive rat/Adrenomedullin/Specific receptor of adrenomedulin分类
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李宏伟,蓝蕊,刘佩东..间歇有氧运动上调自发性高血压大鼠血管肾上腺髓质素[J].中国动脉硬化杂志,2017,25(4):360-364,5.
