中国动脉硬化杂志2017，Vol.25Issue(4)：383-386,4.
冠心病患者血清前蛋白转化酶枯草溶菌素9与小而密低密度脂蛋白胆固醇的相关性研究
Study on the correlation between serum proprotein convertase subtilisin/kexin type 9 and small and dense low density lipoprotein cholesterol in patients with coronary artery disease
韩耀霞 1张强 1边云飞 2张娜娜 1梁斌 2白瑞 2肖传实1
作者信息
- 1. 山西医科大学第一临床医学院心内科,山西省太原市030001
- 2. 山西医科大学第二临床医学院心内科山西省临床心血管药理实验室,山西省太原市030001
- 折叠
摘要
Abstract
Aim To investigate the relationship between serum proprotein convertase subtilisin/kexin type 9 PCSK9) and small and dense low density lipoprotein cholesterol (sdLDLC) in patients with coronary heart disease CHD).Methods From March 2014 to December 2014 in the first hospital of Shanxi Medical University,100 patients with CHD diagnosed by coronary angiography were collected as CHD group,and 67 healthy subjects were served as control group.Lipoprint lipoprotein analyzer was used to measure the LDLC particle size,sdLDLC particle number and the percentage of sdLDLC in LDLC (sdLDLC percentage).Serum PCSK9 level was detected by enzyme-linked immunosorbent assay.Results Compared with the control group,LDLC particle size decreased (264.07 ± 6.78 vs.267.37±5.15,P＜0.01),sdLDLC particle number increased (5.0±9.5 vs.4.0±5.0,P＜0.05),sdLDLC percentage increased (5.95％±10.50％ vs.3.70％±5.85％,P＜0.01) in the CHD group.The serum PCSK9 level in CHD group was significantly higher than that in control group (15.48 μg/L vs.14.95 μg/L,U=-2.74,P=0.006).In the CHD group,serum PCSK9 level was positively correlated with sdLDLC percentage and LDLC (r =0.212,P =0.034;r =0.202,P =0.032).Conclusion Serum PCSK9 level is positively correlated with sdLDLC percentage in patients with CHD,and the inhibition of PCSK9 can prevent CHD.关键词
冠心病/前蛋白转化酶枯草溶菌素9/小而密低密度脂蛋白胆固醇Key words
Coronary heart disease/Proprotein convertase subtilisin/kexin type 9/Small and dense low density lipoprotein cholesterol分类
医药卫生引用本文复制引用
韩耀霞,张强,边云飞,张娜娜,梁斌,白瑞,肖传实..冠心病患者血清前蛋白转化酶枯草溶菌素9与小而密低密度脂蛋白胆固醇的相关性研究[J].中国动脉硬化杂志,2017,25(4):383-386,4.
