Abstract
Objective To explore the prevalence rate of thyroid nodules among Uyghur Nationality in Xinjiang and to analyze the influencing factors of thyroid nodules.Methods A stratified cluster sampling method was used to select Uyghur residents aged from 18 to 80 from Tianshan area in Urumqi of Xinjiang as research objects from September to December 2015.Epidemiological survey form was sent out to investigate the general condition,history of thyroid disease and family history,diet and living habits of the subjects.Physical examination was performed to measure blood pressure,height,body mass,and waist circumference and calculate body mass index (BMI).Fasting venous blood and morning urine were collected,blood glucose,blood lipid,uric acid,glycosylated hemoglobin and urinary iodine were measured.Thyroid ultrasonography was applied to make a definite diagnosis of thyroid nodules.Univariate and multivariate Logistic regression were used to analyze the influencing factors of thyroid nodule.Results Among the included 1 500 subjects,1 268 completed the survey and the actual investigation rate was 84.53％.The rough prevalence rate of developing thyroid nodules was 27.21％ (345/1 268) for research objects,20.49％ (118/576) for men and 32.80％ (227/692) for women.The prevalence rate of women developing thyroid nodules was significantly higher than that of men (x2 =24.080,P ＜ 0.01).The prevalence rate of people aged from 18 to 29,30 to 39,40 to 49,50 to 59 and 60 to 80 developing thyroid nodules was 14.55％ (55/378),16.07％ (45/280),29.93％ (88/294),45.15％ (93/206),and 58.18％ (64/110) respectively,it can be seen that the prevalence rate of thyroid nodules gradually increased with age (x2trend =126.591,P ＜0.01).Univariate Logistic regression analysis showed that female (OR =1.895),age (OR =1.056),habit of mild salt intake (OR =1.697),smoking history (OR =1.431),hypothyroidism (OR =1.555),goiter (OR=6.351),diabetes (OR =2.481),hypertension (OR =2.925),hyperlipidemia (OR =1.928),BMI from 24.0 to 27.9 kg/m2 (OR =1.542) and greater than or equal to 28.0 kg/m2 (OR =2.721),waist circumference (OR =2.639),fasting blood glucose (OR =2.645),OGTT 2 h blood glucose (OR =2.542),systolic blood pressure (OR =3.180),diastolic blood pressure (OR =2.928),TG (OR =1.586),TC (OR =1.714),LDL (OR =1.684),glycosylated hemoglobin (OR =1.864),TSH greater than 4.20 mU/L (OR =1.554),TPOAb (OR =1.479),TGAb (OR =1.581) were the influencing factors of thyroid nodules (P ＜ 0.05).Multivariate Logistic regression analysis showed that gender (OR =2.044),age (OR =1.046) and systolic blood pressure (OR =2.638) were the independent risk factors of thyroid nodules (P ＜0.05).Conclusion As the prevalence rate of thyroid nodules among Uyghur Nationalitv in Xinjiang is relatively high,and there are many risk factors of this disease,especially for female,aged and hypertension,we should achieve early prevention,early diagnosis and early treatment.关键词
甲状腺结节/患病率/影响因素分析Key words
Thyroid nodule/Prevalence/Root cause analysis分类
医药卫生
