中国现代手术学杂志2017，Vol.21Issue(1)：9-13,5.DOI:10.16260/j.cnki.1009-2188.2017.01.003
结直肠癌NOSE术对患者氧化应激、免疫功能及机体微炎症的影响
Effects on Oxidative Stress Reaction, Immune Function and Inflammation during NOSE Radical Surgery for Colorectal Cancer
摘要
Abstract
Objective To explore the effect of oxidative stress reaction,immune function and inflammation during the natural orifice specimen extraction (NOSE) radical surgery for the patients with colorectal cancer.Methods A total of 120 colorectal cancer cases from January 2014 to December 2015 in our hospital were divided into observation group and control group according to random digits table,with 60 cases for each.NOSE surgery was performed in the observation group,and conventional laparoscopic radical resection of colorectal cancer was carried out in the control group.The peri-operative index of intra-operative blood loss,operation time,VAS score of 1 st day after the surgery,postoperative exhaust time,postoperative hospital stay were compared between two groups.The oxidative stress reaction index (SOD、MDA),inflammatory factors (CRP,TNF-α,IL-6,IL-10) and immune function index (NK,CD3 +,CD4 +,CD4 +/CD8 +,IgG,IgM,IgA) were determined and compared.Results The VAS score of 1-day after the operation was lower,and both the gastrointestinal recovery time and hospital stays were shorter in the observation group than those in the control group,the differences were statistical significance (P ＜ 0.05).There was no statistical difference in intra-operative blood loss and operation time between two groups (P ＞ 0.05).In both observation and control groups:The SOD of both T2 and T3 was lower than that of T1,and the SOD of T3 was higher than that of T2(P ＜ 0.05).The MAD、CRP、TNF-α and IL-6 were higher and IL-10 was lower at the time point of T2 and T3 than those of T1,and MDA、CRP、TNF-o、IL-6 was lower and IL-10 was higher at T3 than those at T2(P ＜ 0.05).The CD3 +,CD4 +,IgM and IgA of both T2 and T3 were lower than those of T1,and the CD3 +,CD4 +,IgM and IgA of T3 were higher than those of T2 (P ＜ 0.05).In group comparison:There was no statistical difference in all indexes of T1 between two groups(P ＞0.05).Compared to the control group,the SOD,IL-10,CD3 +,CD4 + and IgM was higher and MAD,CRP,TNF-α and IL-6 was lower in the observation group at the time point of T2 and T3 (P ＜ 0.05).Conclusion Compared with the traditional laparoscopic radical resection,the NOSE radical resection can effectively relieve the oxidative stress reaction,reduce the micro inflammatory factors release,and lessen immune function impact for colorectal cancer.关键词
经自然腔道标本取出术/结直肠癌根治术/结直肠肿瘤/氧化应激/免疫功能/炎症反应Key words
natural orifice specimen extraction (NOSE)/radical resection of colorectal cancer/colorectal neoplasms/oxidative stress/immune function/inflammatory reaction分类
医药卫生引用本文复制引用
丁海涛,帕尔哈提·阿布都热衣木,韩智君,曹杰,迪米拉..结直肠癌NOSE术对患者氧化应激、免疫功能及机体微炎症的影响[J].中国现代手术学杂志,2017,21(1):9-13,5.基金项目
新疆维吾尔自治区自然科学基金资助项目(编号2016D01C217) （编号2016D01C217）
