中国药房2017，Vol.28Issue(13)：1755-1757,3.DOI:10.6039/j.issn.1001-0408.2017.13.08
百部新碱与罗汉果皂苷Ⅴ联用对小鼠的镇咳、祛痰作用研究
Study on the Relieving Cough and Eliminating Phlegm Effects of Stemoninine Combined with Mogroside Ⅴ on Mice
摘要
Abstract
OBJECTIVE:To study the relieving cough and eliminating phlegm effects of stemoninine combined with mogrosideⅤ on mice,and select its optimal ratio. METHODS:70 mice were selected in each experiment and randomly divided into 7 groups,namely solvent group(normal saline), codeine(15 mg/kg)or ambroxol(30 mg/kg)group(positive control),stemoni-nine group(30 mg/kg),mogroside Ⅴ group(30 mg/kg),stemoninine-mogroside Ⅴ combination group(30 mg/kg)with mass ra-tio of 2:1,1:1,1:2,ig,once a day. Ammonia-induced cough experiment(positive drug was codeine)and tracheal phenol red ex-cretion experiment(positive drug was ambroxol)were respectively conducted. Using cough latent period,cough times and volume of tracheal phenol red excretion as indexes,the antitussive and expectorant effects of drug in each group were compared. RE-SULTS:Compared with solvent group,cough latent period was obviously shortened,cough times was obviously reduced,volume of tracheal phenol red excretion was obviously increased in each administration group(P<0.05 or P<0.01). Compared with mogro-side Ⅴ group,cough latent period was obviously shortened,cough times was obviously reduced in stemoninine-mogroside Ⅴgroup with different mass ratios(P<0.05),and 2:1,1:1 groups showed the best effects. Compared with stemoninine group,vol-ume of tracheal phenol red excretion was obviously increased in stemoninine-mogroside Ⅴ group with different mass ratios (P<0.05),and 1:1,1:2 groups showed the best effects. CONCLUSIONS:The combination of temoninine and mogroside Ⅴ shows synergistic effects on relieving cough and eliminating phlegm,stemoninine-mogrosideⅤmass ratio of 2:1,1:1 can be used as pre-ferred combination of reference.关键词
百部新碱/罗汉果皂苷Ⅴ/镇咳/祛痰/小鼠Key words
Stemoninine/MogrosideⅤ/Relieving cough/Eliminating phlegm/Mice分类
医药卫生引用本文复制引用
吴旖,江仁望,赵斌..百部新碱与罗汉果皂苷Ⅴ联用对小鼠的镇咳、祛痰作用研究[J].中国药房,2017,28(13):1755-1757,3.基金项目
广东省省级科技计划项目(No.2013A022100029) （No.2013A022100029）
中山市科技计划项目(No.2015B2306) （No.2015B2306）
广东省一流高职院校建设项目(粤教高函〔2016〕250号) （粤教高函〔2016〕250号）
