中国药房2017，Vol.28Issue(13)：1762-1765,4.DOI:10.6039/j.issn.1001-0408.2017.13.10
小柴胡汤对伊立替康致迟发性腹泻模型小鼠血便的防治作用
Preventive and Treatment Effects of Xiaochaihu Decoction on Irinotecan-induced Bloodystool in Model Mice with Delayed Diarrhea
摘要
Abstract
OBJECTIVE:To investigate the prevention and treatment effect of Xiaochaihu decoction on irinotecan(CPT-11)-in-duced bloodystool in model mice with delayed diarrhea. METHODS:40 mice were randomly divided into normal control group (equal volume of normal saline),model control group(equal volume of normal saline),Xiaochaihu decoction group(1500 mg/kg, calculated by crude drug)and loperamide group(positive control,0.5333 mg/kg),ig,once a day,for 17 days. Except for normal control group,other groups were intraperitoneally injected CPT-11 to induce delayed diarrhea in 4th-10th day. Body mass changes, bloodystool rate of mice were determined,and pathological changes in large intestine and small intestine were observed. RE-SULTS:After 17 days of administration,compared with normal control group,the body mass in modeling groups was obviously declined (P<0.05),while body mass in Xiaochaihu decoction group was higher than model control group (P<0.05). In the 11th-17th day,bloodystool rate in Xiaochaihu decoction group and loperamide group were significantly lower than model control group(P<0.01),and bloodystool rate in Xiaochaihu decoction group was lower than loperamide group(P<0.05). Pathological re-sults showed,obvious diffuse necrosis and inflammatory cell infiltration were observed in mucosal epithelial cells of large intestine and small intestine in model control group,and the intestinal mucosal tissue in administration groups tended to be normal. CON-CLUSIONS:Xiaochaihu decoction can effectively reduce bloodystool rate,improve intestinal mucosa injury,and has prevention and treatment effect on CPT-11-induced bloodystool in mice,with superior effect to loperamide.关键词
小柴胡汤/伊立替康/迟发性腹泻/肠黏膜损伤/血便/小鼠Key words
Xiaochaihu decoction/Irinotecan/Delayed diarrhea/Intestinal mucosa injury/Bloodystool/Mice分类
医药卫生引用本文复制引用
周圆,杨光义,宛蕾..小柴胡汤对伊立替康致迟发性腹泻模型小鼠血便的防治作用[J].中国药房,2017,28(13):1762-1765,4.基金项目
湖北省卫生和计划生育委员会2017-2018年度科研立项项目(No.WJ2017F079) （No.WJ2017F079）
