中国医科大学学报2017，Vol.46Issue(4)：289-293,5.DOI:10.12007/j.issn.0258-4646.2017.04.001
ATP结合盒转运体G1与动脉粥样硬化的研究进展
Role of ATP-binding Cassette Transporter G1 in Atherosclerosis
摘要
Abstract
The adenosine triphosphate (ATP)-binding cassette transporter G1 (ABCG1),a member of the superfamily of ATP-binding cassette transporters,is involved in the efflux of cholesterol and phospholipids from cells,and it maintains the intracellular hpid homeostasis.ABCG1 deficiency results in foam cell formation,endothelial dysfunction,and inflammatory reaction,and it further leads to the development and progression of atherosclerosis.However,the role of ABCG1 in atherosclerosis in animal experiments and human studies is still a debatable matter.In this paper,the recent findings on the role of ABCG1 in atherosclerotic disease are reviewed.关键词
ATP结合盒转运体G1/动脉粥样硬化/单核苷酸多态性Key words
ATP-binding cassette transporter G1/atherosclerosis/single nucleotide polymorphism分类
医药卫生引用本文复制引用
李瞿,张小倩,刘旭,张慧媛,何志义..ATP结合盒转运体G1与动脉粥样硬化的研究进展[J].中国医科大学学报,2017,46(4):289-293,5.基金项目
国家自然科学基金(81070913,81400950) （81070913,81400950）
