中国医科大学学报2017，Vol.46Issue(4)：302-305,4.DOI:10.12007/j.issn.0258-4646.2017.04.004
右美托咪定对谷氨酸诱导的大鼠神经系统毒性作用的影响
Effects of Dexmedetomidine Hydrochloride on Glutamate-induced Neurotoxicity in Rats
摘要
Abstract
Objective To investigate the effects and mechanism of dexmedetomidine hydrochloride preconditioning against glutamate-induced neurotoxicity.Methods The model of glutamate-induced neurotoxicity was established by the injection of glutamate into lateral cerebral ventricle.Thirty-six SD rats were randomly divided into control group (C group),glutamate-induced neurotoxicity group (G group),Dex1 group and Dex2 group.Dex1 group and Dex2 group received intraperitoneal injection of dexmedetomidine respectively at a dose of 50 μg/kg or 100 μg/kg before glutamate application.Two hours later,the rats were sacrificed and hippocampus was separated to measure the level of SOD and MDA.The rest of each brain was used to measure the degree of brain edema.Pathological changes were observed under microscope with Nissl's staining.Results In contrast to G group,brain edema and MDA concentration in Dex1 group and Dex2 group were significant lower,while SOD concentrations were significantly increased and the pathological change in Dex1 group and Dex2 group were relieved obviously compared to glutamate-induced neurotoxicity group.Conclusion Dexmedetomidine preconditioning can significantly attenuate glutamate-induced neurotoxicity,which is properly related to the inhibition of oxidative-stress reaction.关键词
右美托咪定/谷氨酸神经毒性/氧化应激反应Key words
dexmedetomidine/glutamate-induced neurotoxicity/oxidative-stress reaction分类
医药卫生引用本文复制引用
李欣明,李松泽,刘洪涛..右美托咪定对谷氨酸诱导的大鼠神经系统毒性作用的影响[J].中国医科大学学报,2017,46(4):302-305,4.基金项目
国家自然科学基金(81271370) （81271370）
