中国医科大学学报2017，Vol.46Issue(4)：317-320,4.DOI:10.12007/j.issn.0258-4646.2017.04.008
集束化方案治疗急性脑损伤合并急性肺损伤/急性呼吸窘迫综合征疗效分析
Bundles of Treatment Protocol for Acute Brain Injury Complicated by Acute Lung Injury or Acute Respiratory Distress Syndrome
摘要
Abstract
Objective To evaluate the efficacy and safety of the bundles of treatment protocol for patients with acute brain injury (ABI) complicated by acute lung injury (ALl)/acute respiratory distress syndrome (ARDS).Methods A total of 83 patients with acute brain injury complicated by ALI/ARDS were randomly divided into experimental group (n =41) and control group (n =42).The control group was treated with the routine bundle protocol while the experimental group was treated with an intensive bundle protocolin addition to the routine bundle protocol.The data was collected,and the effectiveness and safety of the two bundles of treatment protocol were evaluated.Results The results of heart rate (HR),SpO2,and PO2/FiO2 in the two groups showed significant differences before and after treatment.The improvement of PO2/FiO2 in the experimental group occurred earlier and was more significant compared tothe control group,24 hours after treatment.The mechanical ventilation time,ICU stay time,and total hospitalization time for the experimental group were significantly different (P ＜ 0.05) from the control group.The 28-day mortality and morbidity of ventilator-associated pneumonia showed no significant difference (P ＞ 0.05) between the two groups.Conclusion The treatment of acute brain injury complicated by ALI/ARDS by the two bundles of treatment protocol is effective.Compared to the conventional treatment bundles,the intensive treatment bundles can significantly improve oxygenation,and shorten the mechanical ventilation time required,as well as ICU and total hospital stay.关键词
急性脑损伤/急性肺损伤/急性呼吸窘迫综合征/集束化方案Key words
acute brain injury/acute lung injury/acute respiratory distress syndrome/bundles of treatment protocol分类
医药卫生引用本文复制引用
张恒,王军,仇波,王运杰..集束化方案治疗急性脑损伤合并急性肺损伤/急性呼吸窘迫综合征疗效分析[J].中国医科大学学报,2017,46(4):317-320,4.基金项目
辽宁省自然科学基金(2014021097) （2014021097）
