中国医科大学学报2017，Vol.46Issue(4)：326-329,4.DOI:10.12007/j.issn.0258-4646.2017.04.010
经尿道电灼联合肝素及碱化利多卡因膀胱灌注在间质性膀胱炎治疗中的作用
Transurethral Fulguration with Intravesical Instillation of Heparin and Alkalinized Lidocaine for the Treatment of Interstitial Cystitis
摘要
Abstract
Objective To evaluate transurethral fulguration with intravesical instillation of heparin and alkalinized lidocaine for the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS).Methods Data from the chnical records of 31 patients (30 female and 1 male) with IC/BPS were analyzed retrospectively.Transurethral fulguration and biopsy were performed.Intravesical instillation of heparin and alkalinized lidocaine (25 000 units of hepmin,10 mL of 2％ lidocaine,and 5 mL of 5％ sodium bicarbonate) was administered weekly for 8 weeks.Thereafter,intmvesical instillation treatment was administered twice a month.The interstitial cystitis symptom index and problem index (O'Leary-Sant index),visual analog scale score for pain,quality-of-life index,voiding frequency,bladder capacity,and side effects of intravesical instillation were recorded preoperatively and at the first and sixth month follow-ups postoperatively.Results The follow-up period was 6 to 24 months.The interstitial cystitis symptom index and problem index,visual analog scale score for pain,quality-of-life index,daily voiding time,and maximal bladder volume improved significantly in 28 cases (90.32％;P ＜ 0.01),and no significant adverse effects were observed.Two patients underwent cystectomy,and the symptoms disappeared after the operation.Carcinoma in situ was detected on histopathological examination in one patient.Conclusion Transurethral fulguration with intravesical instillation of heparin and alkalinized lidocaine is a safe and effective therapy for IC/BPS.关键词
间质性膀胱炎/膀胱疼痛综合征/肝素/膀胱灌注/治疗Key words
interstitial cystitis/bladder pain syndrome/heparin/intravesical instillation/treatment分类
医药卫生引用本文复制引用
李振华,于秀月,郭金昊,张鑫,刘忠强,刘娇,孔垂泽..经尿道电灼联合肝素及碱化利多卡因膀胱灌注在间质性膀胱炎治疗中的作用[J].中国医科大学学报,2017,46(4):326-329,4.基金项目
辽宁省教育厅科学技术研究项目(12010635) （12010635）
辽宁省自然科学基金(201102260) （201102260）
