中国医科大学学报2017，Vol.46Issue(4)：345-348,4.DOI:10.12007/j.issn.0258-4646.2017.04.015
视神经脊髓炎谱系疾病患者中水通道蛋白4抗体与视神经损害的相关性
Correlation between Aquaporin-4 Antibody and Optic Neuropathy in Patients with Neuromyelitis Optica Spectrum Disorder
摘要
Abstract
Objective To determine the correlation between aquaporin-4 antibody (AQP4-Ab) and optic neuropathy in patients with neuromyelitis optica spectrum disorder (NMOSD).Methods The clinical and biochemical data of 53 patients with NMOSD diagnosis based on AQP4-Ab level in Changhai Hospital between January 2010 and October 2015 were retrospectively analyzed.According to optic neuropathy occurrence,the NMOSD patients were divided into optic neuropathy and non-optic neuropathy groups.Clinical and biochemical characteristics were compared between the two groups.According to the serum AQP4-Ab levels,the NMOSD patients were divided into AQP4-Ab seropositive and seronegative groups.The incidence of optic neuropathy was compared between the two groups.The correlation between optic neuropathy and AQP4-Ab levels was analyzed.Results Between the optic neuropathy and non-optic neuropathy groups,no significant differences in sex,age at onset,disease course,serum alanine aminotransferase levels,protein levels in cerebral spinal fluid,IgG index,and oligoclonal band were observed (P ＞ 0.05).However,statistically significant differences were found in frequency,superficial sensory impairment,serum creatinine level,and serum AQP4-Ab level (P ＜ 0.05).Between the AQP4-Ab sempositive and semnegative groups,a statistically significant difference in the incidence of optic neuropathy was observed (F =4.93,P ＜ 0.05).The incidence of optic neuropathy positively correlated with AQP4-Ab levels (r =0.297,P ＜ 0.05).Conclusion NMOSD patients with AQP4-Ab seropositivity could be prone to optic neuropathy,and the correlation may be beneficial to early diagnosis,therapy,and monitoring of NMOSD.关键词
视神经脊髓炎谱系疾病/水通道蛋白4抗体/视神经损害/脑脊液Key words
neuromyelitis optica spectrum disorder/aquaporin-4 antibody/optic neuropathy/cerebrospinal fluid分类
医药卫生引用本文复制引用
于鹭,汤可娜,仲星星,李梅,管阳太..视神经脊髓炎谱系疾病患者中水通道蛋白4抗体与视神经损害的相关性[J].中国医科大学学报,2017,46(4):345-348,4.基金项目
上海市优秀学术带头人计划(14XD1403400) （14XD1403400）
