内科2017，Vol.12Issue(2)：185-187,3.DOI:10.16121/j.cnki.cn45-1347/r.2017.02.12
TPF诱导化疗序贯同步放化疗治疗局部晚期鼻咽癌患者疗效分析
Analysis of the curative effect of TPF induction chemotherapy sequential combined with concurrent chemoradiotherapy in the treatment of locally advanced nasopharyngeal carcinoma
陈玉兰 1李曙平 1曾志坚1
作者信息
- 1. 肇庆市第一人民医院肿瘤科,广东省肇庆市 526000
- 折叠
摘要
Abstract
Objective To explore the curative effect and safety of TPF (docetaxel + cisplatin+5-fluorouracil) induction chemotherapy sequential combined with concurrent chemoradiotherapy in the treatment of locally advanced nasopharyngeal carcinoma.Methods A total of 94 patients with locally advanced nasopharyngeal carcinoma in our hospital from November 2012 to May 2013 were selected and divided into the observation group and the control group according to the random number table, with 47 cases in each group.The observation group was treated with TPF induction chemotherapy sequential combined with concurrent chemoradiotherapy, while the control group received concurrent chemoradiotherapy.Both of the groups were treated for 2 weeks.After 3 months of treatment, the clinical curative effect of the two groups were evaluated according to the RECIST reference (in 2000);meanwhile, the adverse reactions were graded according to the common terminology criteria of adverse events (Third Edition) (CTCAEv3.0 in 2003), and the safety of the two schemes was evaluated.Results The total effective rate in the observation group (85.11%) was significantly higher than that in the control group (65.70%,P<0.05);there was no significant difference adverse reaction between the control group(78.7%) and the observation group (80.8%, P>0.05).Conclusions Compare to concurrent chemoradiotherapy, TPF induction chemotherapy combined with concurrent chemoradiotherapy in the treatment of locally advanced nasopharyngeal carcinoma can increase the effective rate, but will not increase the adverse reaction, which shows good security.关键词
鼻咽癌/治疗/TPF/诱导化疗/序贯同步放化疗Key words
Nasopharyngeal carcinoma/Treatment/TPF/Induction chemotherapy/Sequential combined with concurrent chemoradiotherapy分类
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陈玉兰,李曙平,曾志坚..TPF诱导化疗序贯同步放化疗治疗局部晚期鼻咽癌患者疗效分析[J].内科,2017,12(2):185-187,3.
