摘要
Abstract
Objective:To compare the efficacy and safety between radiofrequency ablation (RFA) combined with transcatheter arterial chemoembolization (TACE) and microwave ablation (MWA) combined with TACE.Methods: The clinical data of 85 patients with primary liver cancer were selected from two combined treatment methods, which included RFA combined with TACE (n=50cases) and MWA combined with TACE (n=35cases). A retrospective study was adopted to analyze and compare postoperative complete necrosis rate of lesion, recurrence rate in 3 months, 1 year survival rate and influence on liver function between the two groups.Results: For two liver function indicators (ALT and AST), both of them in MWA combined with TACE group (average values were 108.82±75.74 U/L and 165.51±110.69 U/L, respectively) were significant higher than that in RFA combined with TACE group (average values were 74.35±39.21 U/L and 118.47±50.45 U/L, respectively) (t=4.425,t=4.631; P<0.05). The postoperative total complete necrosis rate of MWA combined with TACE group (87.5%) was significant higher than that of RFA combined with TACE group (77.5%) (x2=3.876,P<0.05). When the diameter of lesion was ≥5 cm, the postoperative complete necrosis rate of MWA combined with TACE group (66.7%) was significant higher than that of RFA combined with TACE group (47.4%) (x2=5.631,P<0.05), at the same time, the postoperative recurrence rate of MWA combined with TACE group was significant lower than that of RFA combined with TACE group (x2=5.102, P<0.05). When the diameter range of lesion was 3 cm and 5cm, both of the difference of postoperative complete necrosis rate between the two groups and the difference of local recurrence rate between the two groups were no significant (x2=0.976, x2=0.224; P>0.05). And the difference of total recurrence rate between the two groups was no significant (x2=0.675,P>0.05). Besides, for the postoperative adverse reaction and 1 year survival rate, the differences between the two groups also were no significant.Conclusion: In the treatment of large and middle primary liver cancer, MWA combined with TACE is better than RAF combined with TACE in the complete necrosis rate and local recurrence rate, but compared with MWA combined with TACE, RAF combined with TACE has little effect on liver function.关键词
肝动脉栓塞化疗/射频消融/微波消融/疗效/安全性Key words
Transcatheter arterial chemoembolization/Radiofrequency ablation/Microwave ablation/Therapeutic efficacy/Security分类
医药卫生
