Abstract
Objective:To investigate clinical characteristics of severe fever with thrombocytopenia syndrome (SFTS) infected by new Bunia virus and analyze the indicators which would affect prognosis.Methods: 42 patients with SFTS infected by new Bunia virus were enrolled and their clinical characteristics were analyzed by this retrospective study. 42 cases were divided into the survival group (40 cases) and the death group (2 cases) according to the survival situation. The series indicator, such as blood routine, liver function and coagulation function, were compared and analyzed between the two group.Results: The 42 cases were sporadic, the main of them were farmers, who were 41 cases (accounting for 97.62%). And the peak period of occurrence of this disease was from June to September. Before the treatment, the values of platelet count and the white blood count were decrease in different degrees among all the patients, while glutamic oxalacetic transaminase, alanine transaminase and creatine kinase were increase to some extent. Among them, 21 cases were with higher amylase, and 6 cases were with renal function damage. After the treatment, the values of white blood count and the platelet count of the 42 patients were significantly higher than those before the treatment (WBC:t=20.401,P<0.001, PLT:t=12.979,P<0.001). The glutamic oxalacetic transaminase, alanine aminotransferase, creatine kinase, prothrombin time, activated partial thromboplastin time and thrombin time of the death group were significantly higher than those of the survival group, and the value of platelet count of death group was significantly lower than that of survival group (t=5.281,P<0.001). 42 cases were sporadic, the majority of which were farmers, accounting for 97.62% (41/42). And June to September is the peak period. All the patients had fever, and the main symptoms were anorexia, fatigue, aching, and the main signs were lymph node swelling, tongue body and limb tremor. 42 cases of platelet count (PLT), the white blood count (WBC) reduced to some extent, aspartate transaminase (AST), alanine transaminase (ALT), creatine kinase (CK) were increased. among them 21 cases of higher amylase, 6 cases of renal damage. After the treatment, the WBC and PLT of 42 patients were significantly higher than before treatment (WBC:t=20.401,P<0.001, PLT:t=12.979,P<0.001), among them 40 cases were cured, but 2 cases died. ALT, AST, CK, prothrombin time (PT), activated partial thromboplastin time (APTT) and thrombin time (TT) of patients in the death group were significantly higher than the survival group, and PLT was significantly lower than that of the survival group (t=5.281,P<0.001).Conclusion: SFTS caused by new Bunia virus has diverse clinical symptoms and signs, and it is often accompanied with abnormal laboratory indicators. Besides, the significant decrease of PLT, and the obvious increases of coagulation function and creatine kinase were the important influencing factors for the death of SFTS patients.关键词
新型布尼亚病毒/发热伴血小板减少综合征/临床特点/预后谷草转氨酶/丙氨酸转氨酶Key words
New Bunia virus/Severe fever with thrombocytopenia syndrome/Clinical characteristics/Prognosis/Aspartate transaminase/Alanine aminotransferase分类
医药卫生
