顺铂治疗非小细胞肺癌的疗效及不良反应与药代动力学关系探讨OACSTPCD
Clinical Efficacy of Cisplatin in Treating Non-Small Cell Lung Cancer and the Relationship Between Adverse Drug Reaction and Pharmacokinetics
目的 探讨顺铂治疗非小细胞肺癌的临床疗效和不良反应与药代动力学的关系.方法 选取医院2015年9月至2016年9月收治的非小细胞肺癌患者42例,给予顺铂20 mg/(m2·d)静脉滴注,连续给药3 d,3周为1个疗程,连续4个疗程,动态采集血清样本检测顺铂药代动力学特点,观察用药过程中的不良反应发生情况及临床疗效.结果 42例非小细胞肺癌患者经顺铂治疗后的临床总有效率为40.47%(17/42),其中疾病控制组的药物浓度-时间曲线(AUC)高于疾…查看全部>>
Objective To investigate the clinical efficacy of Cisplatin in treating patients with non-small cell lung cancer, and the rela-tionship between adverse reactions and pharmacokinetics. Methods Totally 42 patients with non-small cell lung cancer admitted to our hospital from September 2015 to September 2016 were treated with intravenous drip of 20 mg/m2·d of Cisplatin for 3 days, 3 weeks for 1 courses, and the patients received continuous treatment for 4 cours…查看全部>>
王爱珍
江苏省淮安市第二人民医院药剂科,江苏淮安 223002
医药卫生
顺铂非小细胞肺癌药代动力学临床疗效药品不良反应
Cisplatinnon-small cell lung cancerpharmacokineticsclinical efficacyadverse drug reaction
《中国药业》 2017 (7)
9-12,4
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