中国药业2017，Vol.26Issue(8)：5-7,3.DOI:10.3969/j.issn.1006-4931.2017.08.002
2种高脂血症大鼠模型比较
Comparison of Two Models on Hyperlipidemia of Rats
摘要
Abstract
Objective To compare two methods for the preparation of hyperlipidemia rat model,in order to provide a better animal model for the prevention and treatment of hyperlipidemia. Methods In two experiments,the SD rats in normal control group,high fat group, and high fat and high sugar emulsion group were fed for 40 days. The rats in normal control group were fed with normal diet,the rats in high fat group were fed with high fat diet,and the rats in high fat and high sugar emulsion group were fed with high fat and high sugar emulsion diet. After the experiment,the TC,TG,HDL-C and LDL-C and liver histopathological changes were detected. Results Compared with the normal control group,the levels of TC,HDL-C,LDL-C in the highfat feed group were significant increased(P < 0. 01),the levels of TC,TG,HDL-C and LDL-C in the high fat and high sugar emulsion group were significantly increased(P < 0. 01). Histopatholo-gy showed that livers had serious fatty change,it was evident that different degrees of diffuse liver cells of fatty degenera-tion. Conclusion The method of high fat and high sugar emulsion modeling was more suitable for the production of mixed hyperlipi-demia model.关键词
高脂血症/动物模型/造模方法/高脂饲料/高脂高糖乳剂Key words
hyperlipidemia/animal model/modeling method/high fat diet/high fat and high sugar emulsion分类
医药卫生引用本文复制引用
严家荣,王弋,刘盛来,黄小琼,李金凤,邝少松..2种高脂血症大鼠模型比较[J].中国药业,2017,26(8):5-7,3.基金项目
广东省中医药局资助项目[20122200] （）
广东省科技计划项目[2013B060300033,2016A030303026]. （）
